| dc.creator |
Na'was, T. E. |
en_US |
| dc.creator |
Alkaysi, H. N. |
en_US |
| dc.creator |
Abdel-Hay, M. H. |
en_US |
| dc.creator |
Sheikh Salem, M. |
en_US |
| dc.creator |
Gharaibeh, A. M. |
en_US |
| dc.date.accessioned |
2016-04-14T14:12:29Z |
|
| dc.date.available |
2016-04-14T14:12:29Z |
|
| dc.date.datecopyrighted |
1992 |
|
| dc.identifier.issn |
0378-5173 |
en_US |
| dc.identifier.uri |
http://hdl.handle.net/10725/3568 |
|
| dc.description.abstract |
This report describes a spectrophotometric study on the interaction between norfloxacin (NFX) and metal ions (Al3+, Mg2+ and Ca2+). Two buffers of pH 3.6 and 8.8 were used. A shift in absorption maximum was observed and the stoichiometry of the complex was determined using the Job and molar methods. The ratios were NFX:AL3+, 2:1 and 3:1 for the NFX:Mg2+ complex. The formation of a complex with Al3+ enhanced the water solubility of the drug. Microbiological studies indicated decreased activity of norfloxacin in the presence of metal ions. |
en_US |
| dc.language.iso |
en |
en_US |
| dc.title |
Chemical and microbiological investigations of metal ion interaction with norfloxacin |
en_US |
| dc.type |
Article |
en_US |
| dc.description.version |
Published |
en_US |
| dc.creator.school |
SAS |
en_US |
| dc.creator.identifier |
198029370 |
en_US |
| dc.author.woa |
N/A |
en_US |
| dc.creator.department |
Natural Sciences |
en_US |
| dc.description.embargo |
N/A |
en_US |
| dc.relation.ispartof |
International Journal of Pharmaceutics |
en_US |
| dc.description.volume |
87 |
en_US |
| dc.description.issue |
1-3 |
en_US |
| dc.article.pages |
73-77 |
en_US |
| dc.keywords |
Norfloxacin |
en_US |
| dc.keywords |
Norfloxacin-metal ion interaction |
en_US |
| dc.keywords |
Antimicrobial activity |
en_US |
| dc.keywords |
Spectrophotometry |
en_US |
| dc.identifier.doi |
http://dx.doi.org/10.1016/0378-5173(92)90229-U |
en_US |
| dc.identifier.ctation |
Alkaysi, H. N., Abdel-Hay, M. H., Salem, M. S., Gharaibeh, A. M., & Na'was, T. E. (1992). Chemical and microbiological investigations of metal ion interaction with norfloxacin. International journal of pharmaceutics, 87(1), 73-77. |
en_US |
| dc.creator.email |
tnawas@lau.edu.lb |
|
| dc.identifier.url |
http://www.sciencedirect.com/science/article/pii/037851739290229U |
|