An enantioselective synthesis of β2-amino acid derivatives

Elaridi, Jomana; Thaqi, Ali; Prosser, Andrew; Jackson, W. Roy; Robinson, Andrea J.

An enantioselective synthesis of β2-amino acid derivatives

Elaridi, Jomana; Thaqi, Ali; Prosser, Andrew; Jackson, W. Roy; Robinson, Andrea J.; SAS; 201100947; Natural Sciences; jomana.aridi@lau.edu.lb

URI: http://hdl.handle.net/10725/2867

URL: http://www.sciencedirect.com/science/article/pii/S0957416605001473

DOI: http://dx.doi.org/10.1016/j.tetasy.2005.01.048

Date: 2015-12-22

Abstract:

Enantioselective hydrogenation of a series of (E)-α-substituted β-amidoacrylates using Rh(I)-catalysts with chiral phosphine ligands (BPE, DuPHOS) gives β2-amino acid derivatives with enantioselectivities of up to 67%. A β2,3-amino acid derivative was also synthesised with similar enantioselectivity (⩽65%) from the corresponding prochiral enamide.

Citation:

Elaridi, J., Thaqi, A., Prosser, A., Jackson, W. R., & Robinson, A. J. (2005). An enantioselective synthesis of β< sup> 2</sup>-amino acid derivatives. Tetrahedron: Asymmetry, 16(7), 1309-1319.