Regioselective formation of interlocked dicarba bridges in naturally occurring cyclic peptide toxins using olefin metathesis

Elaridi, Jomana; Robinson, Andrea J.; Van Lierop, Bianca J.; Garland, Rebecca D.; Teoh, Euneace; Illesingle, Jayamini P.; Jackson, W. Roy

Regioselective formation of interlocked dicarba bridges in naturally occurring cyclic peptide toxins using olefin metathesis

Elaridi, Jomana; Robinson, Andrea J.; Van Lierop, Bianca J.; Garland, Rebecca D.; Teoh, Euneace; Illesingle, Jayamini P.; Jackson, W. Roy; SAS; 201100947; Natural Sciences; jomana.aridi@lau.edu.lb

URI: http://hdl.handle.net/10725/2864

URL: http://pubs.rsc.org/en/content/articlehtml/2009/cc/b909056h

DOI: http://dx.doi.org/10.1039/B909056H

Date: 2015-12-22

Abstract:

Bis-dicarba analogues of native dicystine-containing α-conotoxin Rg1A, an analgesic peptide isolated from cone snail venom, were constructed on resin using a regioselective metathesis–hydrogenation strategy.

Citation:

Robinson, A. J., van Lierop, B. J., Garland, R. D., Teoh, E., Elaridi, J., Illesinghe, J. P., & Jackson, W. R. (2009). Regioselective formation of interlocked dicarba bridges in naturally occurring cyclic peptide toxins using olefin metathesis. Chemical Communications, (28), 4293-4295.