El-Sibai, Mirvat; Zreik, Tony G.; Zalloua, Pierre A.; Abchee, Antoine; Youhanna, Sonia; Makhoul, Nadine; Puzantian, Houry; Sawaya, Jaber; Nasrallah, Antoine; Abdallah, Rebeiz; Yerezian, Joumana; Azar, Sami; Hanine, Estephan; SAS; 200703859; 200802707; 200300001; Natural Sciences; mirvat.elsibai@lau.edu.lb; tgzreik@lau.edu.lb; pierre.zalloua@lau.edu.lb
Abstract:
Background: Mutations in genes regulating lipid metabolism, vasoactivity, and coagulation are important modulators of coronary artery disease (CAD).
Objective: This study investigated the association between allelic variants of the angiotensin converting enzyme (ACE), methytetrahydrofolate reductase, plasminogen activator inhibitor-1 and factor V genes and CAD.
Methods: Clinical, biochemical, and angiographic information were collected from 300 patients who underwent cardiac catheterization and their DNA was genotyped by restriction fragment length polymorphism.
Results: The frequency of the D allele of the ACE gene was significantly higher than the I allele in patients with more than 70% stenosis in any vessel. Among patients with more than 70% stenosis, carriers of the D allele were 2.8 times more likely to be males. The presence of the ACE I allele was negatively associated with CAD with (P=0.02 ,OR=0.38.)
Conclusion: This study describes a protective role of the ACE I allele in individuals who may be at risk of developing CAD.
Citation:
Abchee, A., El-Sibai, M., Youhanna, S., Yeretzian, J. S., Estephan, H., Makhoul, N. J., ... & Zreik, T. G. (2010). The I allele of the angiotensin converting enzyme I/D polymorphism confers protection against coronary artery disease. Coronary artery disease, 21(3), 151-156.