Magnetic property, DFT calculation, and biological activity of bis[(μ2-chloro)chloro(1,10-phenanthroline)copper(II)] complex

Mroueh, Mohamad; Daher, Costantine; Hariri, Essa; Demirdjian, Sally; Isber, Samih; Choi, Eun Sang; Mirtamizdoust, Babak; Hammud, Hassan H.

Magnetic property, DFT calculation, and biological activity of bis[(μ2-chloro)chloro(1,10-phenanthroline)copper(II)] complex

Mroueh, Mohamad; Daher, Costantine; Hariri, Essa; Demirdjian, Sally; Isber, Samih; Choi, Eun Sang; Mirtamizdoust, Babak; Hammud, Hassan H.; SAS; SOP; 199190130; 199590020; Natural Sciences; mmroueh@lau.edu.lb; cdaher@lau.edu.lb

URI: http://hdl.handle.net/10725/2814

URL: http://www.sciencedirect.com/science/article/pii/S0009279715000927

DOI: http://dx.doi.org/10.1016/j.cbi.2015.02.023

Date: 2015-12-16

Abstract:

The dinuclear complex bis[(μ2-chloro)chloro(1,10-phenanthroline)copper(II)] (1) was synthesized, and characterized by X-ray, FTIR and thermal analysis. The fitting of magnetic susceptibility and magnetization curve of (1) indicates the occurrence of weak antiferromagnetic exchange interaction between copper(II) ions. The electronic structure has been also determined by density functional theory (DFT) method. Complex (1) displayed potent anticancer activity against B16 (Melanoma), MDA-MB-32 (Breast Adenocarcinoma), A549 (Lung Adenocarcinoma), HT-29 (Colon Adenocarcinoma) and SF (Astrocytoma) cell lines with an average IC50 value of 0.726 μg/ml compared to 4.88 μg/ml for cisplatin. Complex (1) has a better therapeutic index and toxicological profile than cisplatin, and has demonstrated a potential chemotherapeutic property.

Citation:

Mroueh, M., Daher, C., Hariri, E., Demirdjian, S., Isber, S., Choi, E. S., ... & Hammud, H. H. (2015). Magnetic property, DFT calculation, and biological activity of bis [(μ 2-chloro) chloro (1, 10-phenanthroline) copper (II)] complex. Chemico-biological interactions, 231, 53-60.