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SOM - Scholarly Publications: Recent submissions

Now showing items 101-120 of 780

MPTP neurotoxicity and the “biochemical” blood-brain barrier

SOM; 200902731; N/A; Riachi, Naji J.; naji.riachi@lau.edu.lb; Lebanese American University (Springer, )
Design and synthesis of 18F-labeled neurotoxic analogs of MPTP

Riachi, Naji J.; Berridge, Marc S.; Sayre, Lawrence M.; Arora, Pramod K.; Terris, Andrew H.; Harik, Sami I.

We report on the synthesis of two fluorine-18 labeled analogs of l-methyl-4-phenyl-1, 2, 3, 6- tetrahydropyridine (MPTP). A piperidyl triazene was fluorinated to produce [18F]-l-methyl-4- (2-fluorophenyl)-l, 2, 3, ...
Monoamine oxidases of the brains and livers of macaque and cercopithecus monkeys

Riachi, Naji I.; Harik, Sami I.

We assessed the two forms of monoamine oxidase (MAO), MAO-A and MAO-B, in discrete regions of the brain and in cerebral micro- and macrovessels, choroid plexus, and liver of three species of monkeys: African Green, rhesus, ...
Effects of internal carotid administration of MPTP on rat brain and blood-brain barrier

Riachi, Naji J.; Dietrich, W. Dalton; Harik, Sami I.

Unlike primates, rats are resistant to systemic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity, but direct infusion of MPTP into rat substantia nigra causes specific destruction of dopaminergic neurons. ...
Potent neurotoxic fluorinated 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine analogs as potential probes in models of parkinson disease

Riachi, Naji J.; Arora, Pramod K.; Sayre, Lawrence M.; Harik, Sami I.

We synthesized a number of fluorinated analogs of 1‐methyl‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP), and tested their suitability as substrates for monoamine oxidase B in vitro and their dopaminergic neurotoxicity in ...
Chemical oxidation of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) and its in vivo metabolism in rat brain and liver

Riachi, Naji J.; Arora, Pramond K.; Sayre, Lawrence M.

We investigated in vivo the metabolism of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) in the brain and liver of rats 45 min after the systemic administration of 50 mg/kg of the neurotoxin. The metabolites present ...
Correlation of MPTP neurotoxicity in vivo with oxidation of MPTP by the brain and blood-brain barrier in vitro in five rat strains

Riachi, Naji J.; Behmand, Ramin A.; Harik, Sami I.

We studied 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) neurotoxicity in 5 strains of rats by assessing mortality and brain monoamine changes after MPTP injections into the internal carotid artery. We then attempted ...
Structure-neurotoxicity trends of analogues of 1-methyl-4-phenylpyridinium (MPP+), the cytotoxic metabolite of the dopaminergic neurotoxin MPTP

Riachi, Naji J.; Arora, Pramod K.; Fiedler, G.Curt; Singh, Malvinder P.; Abdallah, Fares; Harik, Sami I.

The dopaminergic neurotoxicity of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) derives from its metabolism to 1-methyl-4-phenylpyridinium cation (MPP+), which is then selectively accumulated in dopaminergic ...
Entry of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine into the rat brain

Riachi, N.J.; LaManna, J.C.; Harik, S.I.

We studied blood-to-brain entry of 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP), 1-methyl-4-phenylpyridinium (MPP+) and butanol in anesthetized rats using the indicator-fractionation method with right atrial bolus ...
Dopaminergic neurotoxicity in vivo and inhibition of mitochondrial respiration in vitro by possible endogenous pyridinium‐like substances

Riachi, Naji I.; Sayre, Lawrence M.; Wang, Fengjiang; Arora, Pramod K.; Harik, Sami I.; Hoppel, Charles L.

Elucidation of the mechanism(s) by which 1‐methyI‐4‐phenyl‐1,2,3,6‐tetrahydropyridine (MPTP) and its active metabolite l‐methyl‐4‐phenylpyridinium (MPP+) cause parkinsonism in humans and other primates has prompted ...
Strain differences in systematic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine neurotoxicity in mice correlate best with monoamine oxidase activity at the blood-brain barrier

Riachi, Naji J.; Harik, Sami I.

We measured monoamine oxidase activity in the cerebral cortex, striatum and brain microvessels of two mouse strains that differ in their susceptibility to systemic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPIP) ...
Posterior reversible encephalopathy syndrome (PRES) in mesenteric leiomyosarcoma

Ahdab, Rechdi; Nicolas, Gregory; Schoucair, Ramy; Bejjani, Noha; Abdalla, Eddie K.

Background Posterior reversible encephalopathy syndrome (PRES) is a syndrome characterized by headache, confusion, visual loss and seizures. Many factors influence the appearance of this syndrome, predominantly eclampsia, ...
The ulnar ratio as a sensitive and specific marker of acute inflammatory demyelinating polyneuropathy

Ahdab, Rechdi; Noureldine, Mohammad Hassan A.; Nader, Manal; Mohammedi, Kamel; Zouari, HEla G.; Zouari, Hela G.; Nordine

Objectives To explore the value of a novel sensory criterion, the ulnar ratio – defined as the SNAP amplitude of the palmar cutaneous (pUN) over that of the dorsal branch (dUN) of the ulnar nerve – as a predictor of Acute ...
Action-induced clonus

Ahdab, Rechdi; Ayache, Samar S.; Gracies, Jean-Michel; Farhat, Wassim H.; Fenelon, Gilles; Lefaucheur, Jean-Pascal
Miller Fisher syndrome presenting as palate paralysis

Ahdab, Rechdi; Sweid, Ahmad; Noureldine, Mohammad Hassan A.

We report a 63-year old patient who presented to our care initially with a hypernasal voice followed by ataxia, ptosis, dysphonia, and paresthesias. The patient's history, physical examination, and additional tests led to ...
Permanent reversal of essential tremor following a frontal lobe stroke

Ahdab, Rechdi; Chalah, Moussa A.; Ayache, Samar S.; Riachi, Naji

Following a right prerolandic stroke, a 76 year old woman with bilateral upper extremity essential tremor (ET) recovered permanently from the latter contralaterally to the affected hemisphere. The ischemic stroke likely ...
The hand motor hotspot is not always located in the hand knob

Ahdab, Rechdi; Ayache, Samar S.; Brugieres, Pierre; Farhat, Wassim H.; Lechauffeur, Jean-Pascal

The hand motor hot spot (hMHS) is one of the most salient parameters in transcranial magnetic stimulation (TMS) practice, notably used for targeting. It is commonly accepted that the hMHS corresponds to the hand representation ...
Reappraisal of the anatomical landmarks of motor and premotor cortical regions for image‐guided brain navigation in TMS practice

Ahdab, Rechdi; Ayache, Samar S.; Farhat, Wassim S.; Mylius, Veit; Schmidt, Sein; Brugieres, Pierre; Lefaucheur, Jean-Pascal

Image‐guided navigation systems dedicated to transcranial magnetic stimulation (TMS) have been recently developed and offer the possibility to visualize directly the anatomical structure to be stimulated. Performing navigated ...
Effects of left DLPFC versus right PPC tDCS on multiple sclerosis fatigue

Ahdab, Rechdi; Chalah, Moussa A.; Riachi, Naji; Mhalla, Alaa; Abdellaoui, Mohamed; Creange, Alain; Lefaucheur, Jean-Pascal; Ayache, Samar S.

Background and objective Fatigue is a frequent and debilitating symptom in patients with multiple sclerosis (MS). Its classical treatments are still faced with limited benefits and numerous side effects. Hence, we aimed ...
Motor neuron disorder with tongue spasms due to pyrethroid insecticide toxicity

Ahdab, R.; Ayache, S.S.; Brugieres, P.; Lefaucheur, J.-P.; Maltonti, F.

Now showing items 101-120 of 780

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