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SOP - Scholarly Publications: Recent submissions

  • Confirmation of iminoacridan structure of singly protonated 9-aminoacridine 
    Capomacchia, Anthony C.; Schulman, Stephen G.
    The occurrence of the second absorption band of singly protonated 9-aminoacridine, which arises from an acridinium ring-localized transition, at anomalously short wavelength indicates the disruption of the aromaticity of ...
  • Electronic spectra and electronic structures of some antimicrobials derived from proflavine 
    Capomacchia, Anthony C.; Schulman, Stephen G.; Naik, Datta V.; Roy, Timothy
    The shifts in the absorption and fluorescence spectra of 3-aminoacridine, proflavine, acridine orange, and acridine yellow were employed to show that the singly charged cations, the predominant species at biological pH, ...
  • Electronic absorption and fluorescence spectrophotometry of quinacrine 
    Capomacchia, Anthony C.; Schulman, Stephen G.; SOP; 201408778; Pharmaceutical Sciences Department; anthony.capomacchia@lau.edu.lb; Lebanese American University
    The absorption and fluorescence spectra of quinacrine and its dealkylated derivative, 2-methoxy-6-chloro-9-aminoacridine, were studied as a function of pH and Hammett acidity. The relative stability and high quantum yield ...
  • Analysis of chlortetracycline by high performance liquid chromatography with postcolumn alkaline-induced fluorescence detection 
    Capomacchia, Anthony C.; Bryan, Peter D.; Hawkins, Kristina R.; Stewart, James T.; SOP; 201408778; Pharmaceutical Sciences Department; anthony.capomacchia@lau.edu.lb; Lebanese American University
    A high performance liquid chromatographic method for the analysis of chlortetracycline (CTC) using postcolumn fluorescence detection has been developed. After chromatographic separation of CTC on a polystyrenedivinylbenzene ...
  • Valence tautomerism of singly protonated 9-aminoacridine and its implications for intercalative interactions with nucleic acids 
    Capomacchia, Anthony C.; Casper, Jay; Schulman, Stephen G.; SOP; 201408778; Pharmaceutical Sciences Department; anthony.capomacchia@lau.edu.lb; Lebanese American University
    Electronic absorption and fluorescence spectroscopy were used to show that the singly protonated 9-aminoacridine cation exists as the vinylogous cyclic amidine valence tautomer, the 9-iminoacridan monocation, in ground and ...
  • Fluorescence of 6-methoxyquinoline, quinine, and quinidine in aqueous media 
    Capomacchia, Anthony C.; Threatte, Rose Marie; Schulman, Stephen C.; SOP; 201408778; Pharmaceutical Sciences Department; anthony.capomacchia@lau.edu.lb; Lebanese American University
    The absorption and fluorescence spectra of 6-methoxy-quinoline, quinine, and quinidine were studied as a continuous function of pH. 6-Methoxyquinoline is a stronger base in the lowest excited singlet state, as reflected ...
  • Accelerated dissolution testing for controlled release microspheres using the flow-through dissolution apparatus 
    Capomacchia, A.C.; Collier, Jarrod W.; Thakare, Mohan; Ahmed, Hisham; Graner, Solomon T.; Israel, Bridgette; Granade, Saundra; SOP; 201408778; Pharmaceutical Sciences Department; anthony.capomacchia@lau.edu.lb; Lebanese American University
    Theophylline controlled release capsules (THEO-24 CR) were used as a model system to evaluate accelerated dissolution tests for process and quality control and formulation development of controlled release formulations. ...
  • Physicochemical studies of binary eutectic of ibuprofen and ketoprofen for enhanced transdermal drug delivery 
    Capomacchia, Anthony Cesare; Yuan, Xudong; SOP; 201408778; Pharmaceutical Sciences Department; anthony.capomacchia@lau.edu.lb; Lebanese American University
    Methods: The thermodynamic, eutectic, and crystalline properties of ibuprofen and ketoprofen binary mixtures were investigated using differential scanning calorimetry (DSC) and X-ray powder diffractometry (XRPD). Results: ...
  • Formulation parameters and release mechanism of theophylline loaded ethyl cellulose microspheres 
    Capomacchia, Anthony C.; Thakare, Mohan; Graner, Solomon T.; Ahmed, Hisham; Graner, Pamela; Elder, Deborah; Price, James C.; Israel, Bridgette; SOP; 201408778; Pharmaceutical Sciences Department; anthony.capomacchia@lau.edu.lb; Lebanese American University
    Altering the combined hydrophilic-lipophilic balance (CHLB), by varying the ratio of dual surfactants, on formulation parameters and in vitro drug release of ethyl cellulose microspheres was examined. Theophylline, a ...
  • Influence of physicochemical properties on the in vitro skin permeation of the enantiomers, racemate, and eutectics of ibuprofen for enhanced transdermal drug delivery 
    Capomacchia, Anthony C.; Yuan, Xudong; SOP; 201408778; Pharmaceutical Sciences Department; anthony.capomacchia@lau.edu.lb; Lebanese American University
    Physicochemical properties of chiral ibuprofen are significant to formulation scientists because its enantiomers and eutectics possess lower melting points than its racemate. The influence of these properties on transdermal ...
  • Potentially inappropriate medications use in community-based aged patients: a cross-sectional study using 2012 Beers criteria 
    Kuyumjian, Yara-Mary; Wakim, Samira; Zeeny, Rony; SOP; 200802837; Pharmacy Practice Department; yara-mary.kouyoumdjian@lau.edu.lb; Lebanese American University
    Background Potentially inappropriate medications (PIMs) should be avoided by the aged population. The aim of this study was to assess the prevalence of PIMs among Lebanese aged outpatients using Beers criteria of 2012. ...
  • Idarucizumab, a humanized, monoclonal antibody fragment for immediate reversal of dabigatran 
    Kuyumjian, Yara; Miyares, Marta A.; Eaves, Shannon; SOP; 200802837; Pharmacy Practice Department; yara-mary.kouyoumdjian@lau.edu.lb; Lebanese American University
    Objective: To evaluate the role of idarucizumab, a humanized monoclonal antibody fragment, as a specific reversal agent for the anticoagulant activity of dabigatran and to review the pharmacology, pharmacokinetic properties, ...
  • A multidisciplinary team-based process improves outpatient anticoagulation quality with continuous-flow left-ventricular assist devices 
    Kuyumjian, Yara M.; Miyares, Marta A.; Leverock, Jaime; Chaparro, Sandra; Baker, William L.; jennings, Douglas L.; SOP; 200802837; Pharmacy Practice Department; yara-mary.kouyoumdjian@lau.edu.lb; Lebanese American University
    While continuous-flow left-ventricular assist devices (CF-LVAD) prolong survival in patients with heart failure who are refractory to medical therapy [1], contemporary devices expose patients to a superposed risk of both ...
  • Synthesis of new pyrazolo[3,4-d]pyrimidine derivatives and evaluation of their anti-inflammatory and anticancer activities 
    Mroueh, Mohamad; Faour, Wissam H.; Daher, Costantine F.; Abd El Razik, Heba A.; Shebaby, Wassim N.; Ashour, Hayam M.; Ragab, Hanan M.; SAS; SOM; SOP; 199590020; 200904962; 199190130; Natural Sciences; mmroueh@lau.edu.lb; wissam.faour@lau.edu.lb; cdaher@lau.edu.lb; Lebanese American University
    This study reports the synthesis of two series of new purine bioisosteres comprising a pyrazolo[3,4-d]pyrimidine scaffold linked to piperazine moiety through different amide linkages. The newly synthesized compounds were ...
  • Wild carrot pentane-based fractions suppress proliferation of human HaCaT keratinocytes and protect against chemically-induced skin cancer 
    Mroueh, Mohamad A.; Ishac Taleb, Robin; El-Sibai, Mirvat; Daher, Costantine F.; Shebaby, Wassim N.; Boukamp, Petra; Bodman-Smith, Kikki; N/A; SOP; 199590020; 200901968; 200703859; 199190130; N/A; cdaher@lau.edu.lb; mirvat.elsibai@lau.edu.lb; robin.taleb@lau.edu.lb; mmroueh@lau.edu.lb; Lebanese American University
    Background Previous studies in our laboratory showed that the Lebanese Daucus carota ssp. carota (wild carrot) oil extract possesses in vitro and in vivo anticancer activities. The present study aims to examine the cytotoxic ...
  • Cafeteria diet-fed mice is a pertinent model of obesity-induced organ damage 
    Zeeni, Nadine; Dimassi, Hani; Faour, Wissam H.; Dagher-Hamalian, Carole; SAS; SON; SOM; SOP; 201000400; 200603781; 200904962; 200902770; Natural Sciences; nadine.zeeni@lau.edu.lb; hani.dimassi@lau.edu.lb; wissam.faour@lau.edu.lb; carole.hamalian@lau.edu.lb; Lebanese American University
    Objective This study is aimed at evaluating the effects of a cafeteria diet (obesity) mouse model on early multi-organ functional, structural, endocrine and biochemical alterations. Materials and methods Multi-organ ...
  • Daucus carota pentane/diethyl ether fraction inhibits motility and reduces invasion of cancer cells 
    Daher, Costantine F.; Mroueh, Mohamad; Taleb, Robin I.; El-Sibai, Mirvat; Zgheib, Perla; Nasrallah, Anita; SAS; SOP; 199190130; 199590020; 200901968; 200703859; Natural Sciences; cdaher@lau.edu.lb; mmroueh@lau.edu.lb; robin.taleb@lau.edu.lb; mirvat.elsibai@lau.edu.lb; Lebanese American University
    Daucus carota (DC) is a herb used in folklore medicine in Lebanon to treat numerous diseases including cancer. Recent studies in our laboratory on DC oil and its fractions revealed potent anticancer activities in vitro and ...
  • Traumatic inferior epigastric vessel haemorrhage 
    Dimassi, Hani; Mohammed, Babiker Ali; Alshehri, Fahad Mohammed; SOP; 200603781; N/A; hani.dimassi@lau.edu.lb; Lebanese American University
    Inferior epigastric vessel (IEV) bleeding usually results in a localised rectus sheath haematoma. This condition was thought to be uncommon and sometimes overlooked or misdiagnosed. Lately the condition has become more ...
  • Survey and analysis of internal temperatures of Lebanese domestic refrigerators 
    Hassan, Hussein F.; Dimassi, Hani; El Amin, Rafal; SOP; SAS; 201200056; 200603781; N/A; hussein.hassan@lau.edu.lb; hani.dimassi@lau.edu.lb; Lebanese American University
    In the light of power crisis that Lebanon is witnessing, temperatures were recorded, using data loggers, in 147 domestic refrigerators in three main cities every 5 min over 3 days. A questionnaire was administered to gather ...
  • Distribution and predictors of emergency department charges 
    Dimassi, Hani; Saleh, Shadi; Mourad, Yara; Hitti, Eveline; SOP; 200603781; N/A; hani.dimassi@lau.edu.lb; Lebanese American University
    Background: As health care costs continue to increase worldwide, health care systems, and more specifically hospitals are facing continuous pressure to operate more efficiently. One service within the hospital sector ...

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