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SOP - Scholarly Publications: Recent submissions

  • Buccal Cell DNA Extraction 
    Saab, Yolande B.; Kabbara, Wissam; Chebib, Christiane; Gard, Paul Richard; SOP; 199110360; 200104485; N/A; ysaab@lau.edu.lb; wissam.kabbara@lau.edu.lb
    Simple and cost-effective methods are needed to extract DNA in order to use it in large-scale studies. Blood is an excellent DNA source; however, it is costly and invasive thus an alternative is needed. Several kits and ...
  • Inappropriate Medication Use in Elderly Lebanese Outpatients 
    Saab, Yolande B.; Hachem, Alya; Sinno, Soha; El-Moalem, Habib; SOP; 199110360; N/A; ysaab@lau.edu.lb
    Background Inappropriate use of medications has become an international cause for concern in geriatric patients, who are at high risk of drug-related morbidity. This study is the first attempt to determine the prevalence ...
  • Amoxicillin/Clavulanic Acid-Induced Thrombocytopenia 
    Saad, Aline; Mansour, Hanine; Azar, Marina; Khoueiry, Paul; SOP; 200703818; 201205628; N/A; aline.saad@lau.edu.lb; hanine.mansour@lau.edu.lb
    Introduction and Objective: Drug-induced thrombocytopenia is a common adverse effect reported in the literature. Typically patients present with a low platelet count with signs and symptoms ranging from bruising to ...
  • Hints for success in ASHP's Clinical Skills Competition 
    Saad, A; Der-Nigoghossian, CA; Eldebs, M; Karaoui, LR; Saad, A; SOP; 200703818; N/A; aline.saad@lau.edu.lb
  • Physicians' attitudes toward clinical pain management and education 
    Nasser, Soumana C.; Saad, Aline Hanna; Nassif, Jeanette G.; SOP; 199231640; 200703818; N/A; soumana.nasser@lau.edu.lb; aline.saad@lau.edu.lb
    Despite promising initiatives to advance the practice of pain management in Middle Eastern countries, their pain care lags behind developed countries. The objectives of this study are to evaluate physicians’ assessment of ...
  • Mapping and assessment of personal and professional development skills in a pharmacy curriculum 
    Saad, Aline Hanna; Btaiche, Imad F.; Ramia, Elsy; Salameh, Pascale; SOP; 200703818; 201105289; 200302267; N/A; aline.saad@lau.edu.lb; imad.btaiche@lau.edu.lb; elsy.ramia@lau.edu.lb
    Background Health sciences programs are increasingly expanding their curricula to bridge foundational scientific knowledge with needed skills to practice and patient care. The primary objectives of this study are to 1) ...
  • Pharmacist recognition of and adherence to medication-use policies and safety practices 
    Saad, Aline; Sweet, Burgunda; Stumpf, Janice; Gruppen, Larry; Oh, Mary; Stevenson, James; SOP; 200703818; N/A; aline.saad@lau.edu.lb
    Purpose. Pharmacist recognition of and adherence to medication-use policies and safety practices were assessed. Methods. Simulation testing was used to assess the performance of pharmacists in hypothetical scenarios ...
  • Factors Influencing the Magnitude and Clinical Significance of Drug Interactions Between Azole Antifungals and Select Immunosuppressants 
    Saad, Aline; SOP; 200703818; N/A; aline.saad@lau.edu.lb
    The magnitude of drug interactions between azole antifungals and immunosuppressants is drug and patient specific and depends on the potency of the azole inhibitor involved, the resulting plasma concentrations of each drug, ...
  • Association of hypertension with coronary artery disease onset in the Lebanese population 
    Milane, Aline; Abdallah, Jad; Kanbar, Roy; Khazen, Georges; Saad, Aline; Zalloua, Pierre; Ghassibe-Sabbagh, Michella; Salloum, Angelique K.; El Bayeh, Hamid; Chammas, Elie; Platt, Daniel E.; Hager, Jorg; Gauguier, Dominique; Youhanna, Sonia; Abchee, Antoine; SOP; SAS; 200904164; 200703820; 201005298; 201105253; 200703818; 200300001; Pharmaceutical Sciences Department; aline.milane@lau.edu.lb; jabdallah@lau.edu.lb; roy.kanbar@lau.edu.lb; GKhazen@lau.edu.lb; aline.saad@lau.edu.lb; pierre.zalloua@lau.edu.lb
    The onset of coronary artery disease (CAD) is influenced by cardiovascular risk factors that often occur in clusters and may build on one another. The objective of this study is to examine the relationship between hypertension ...
  • Prevalence of depression in Parkinson’s disease in a Lebanese tertiary clinic 
    Khazen, Georges; Abdallah, Jad; Milane, Aline; Ghaddar, Alissar; Fawaz, Mohammad; SAS; SOP; 201105253; 200703820; 200904164; N/A; GKhazen@lau.edu.lb; jabdallah@lau.edu.lb; aline.milane@lau.edu.lb
    Diagnosis of Parkinson’s disease can be emotionally and psychologically challenging to patients. The aim of this study is to investigate the association between Parkinson’s disease and depression and the impact of the ...
  • The DJ-1 superfamily member Hsp31 repairs proteins from glycation by methylglyoxal and glyoxal 
    Abdallah, Jad; Mihoub, Mouadh; Gontero, Brigitte; Dairou, Julien; Richarme, Gilberte; SOP; 200703820; N/A; Pharmaceutical Sciences Department; jabdallah@lau.edu.lb
    Hsp31 belongs to the PfpI/Hsp31/DJ-1 superfamily, and has been reported to display chaperone, peptidase and glutathione-independent glyoxalase activities. Here, we show that Hsp31 repairs glyoxal- and methylglyoxal-glycated ...
  • The DJ-1 superfamily members YhbO and YajL from Escherichia coli repair proteins from glycation by methylglyoxal and glyoxal 
    Abdallah, Jad; Mihoub, Mouadh; Gautier, Valeire; Richarme, Gilbert; SOP; 200703820; N/A; jabdallah@lau.edu.lb
    YhbO and YajL belong to the PfpI/Hsp31/DJ-1 superfamily. Both proteins are involved in protection against environmental stresses. Here, we show that, like DJ-1 and Hsp31, they repair glyoxal- and methylglyoxal-glycated ...
  • Protein Isoaspartate Methyltransferase Is a Multicopy Suppressor of Protein Aggregation in Escherichia coli 
    Abdallah, Jad; Kern, Renee; Malki, Abderrahim; Lebart, Jean-Claude; Dubucs, Catherine; Hee Yu, Myeong; Richarme, Gilbert; SOP; 200703820; N/A; jabdallah@lau.edu.lb
    We used preS2-S′-β-galactosidase, a three-domain fusion protein that aggregates extensively at 43°C in the cytoplasm of Escherichia coli, to search for multicopy suppressors of protein aggregation and inclusion body formation ...
  • The thioredoxin homolog YbbN functions as a chaperone rather than as an oxidoreductase 
    Abdallah, Jad; Kthiri, Fatoum; Le, Hai-Tuong; Tagourti, Jihen; Kern, Renee; Malki, Abderrahim; Caldas, Teresa; Landoulsi, Ahmed; Richarme, Gilbert; SOP; 200703820; Pharmacy; jabdallah@lau.edu.lb
    Escherichia coli contains two thioredoxins, Trx1 and Trx2, and a thioredoxin-like protein, YbbN, which presents a strong homology in its N-terminal part with thioredoxins, and possesses a 20 kDa C-terminal part of unknown ...
  • Cloning, expression, and purification of the general stress protein YhbO from Escherichia coli 
    Abdallah, Jad; Kern, Renee; Malki, Abderrahim; Eckey, Viola; Richarme, Gilbert; SOP; 200703820; N/A; Pharmaceutical Sciences Department; jabdallah@lau.edu.lb
    We cloned, expressed, and purified the Escherichia coli yhbO gene product, which is an aminoacid sequence homolog to the Bacillus subtilis general stress protein 18 (the yfkM gene product), the Pyrococcus furiosus intracellular ...
  • The Escherichia coli thioredoxin homolog YbbN/Trxsc is a chaperone and a weak protein oxidoreductase 
    Abdallah, Jad; Malki, Abderrahim; Kern, Renee; Richarme, Gilbert; SOP; 200703820; N/A; jabdallah@lau.edu.lb
    Escherichia coli contains two thioredoxins, Trx1 and Trx2, and a thioredoxin-like protein, YbbN, which presents a strong homology in its N-terminal part with thioredoxin 1 and 2. YbbN, however, does not possess the canonical ...
  • YhbO Protects Cells against Multiple Stresses 
    Abdallah, Jad; Caldas, Teresa; Kthiri, Fatoum; Kern, Renee; Richarme, Gilbert; SOP; 200703820; N/A; jabdallah@lau.edu.lb
    YhbO is a member of the DJ-1/ThiJ/Pfp1 superfamily, which includes chaperones, peptidases, and the Parkinson's disease protein DJ-1. A yhbO-disrupted mutant of Escherichia coli is highly sensitive to oxidative, thermal, ...
  • Solubilization of Protein Aggregates by the Acid Stress Chaperones HdeA and HdeB 
    Abdallah, Jad; Malki, Abderrahim; Le, Hai-Tuong; Milles, Sigrid; Kern, Renee; Caldas, Teresa; Richarme, Gilbert; SOP; 200703820; N/A; jabdallah@lau.edu.lb
    The acid stress chaperones HdeA and HdeB of Escherichia coli prevent the aggregation of periplasmic proteins at acidic pH. We show in this report that they also form mixed aggregates with proteins that have failed to be ...
  • Characterization of the Escherichia coli YedU protein as a molecular chaperone 
    Abdallah, Jad; Malki, Abderrahim; Kern, Renee; Richarme, Gilbert; SOP; 200703820; N/A; jabdallah@lau.edu.lb
    We have cloned, purified to homogeneity, and characterized as a molecular chaperone the Escherichia coli YedU protein. The purified protein shows a single band at 31 kDa on SDS–polyacrylamide gels and forms dimers in ...
  • Escherichia coli HdeB Is an Acid Stress Chaperone 
    Abdallah, Jad; Kern, Renee; Malki, Abderrahim; Tagourti, Jihen; Richarme, Gilbert; SOP; 200703820; Pharmacy; jabdallah@lau.edu.lb
    We cloned, expressed, and purified the hdeB gene product, which belongs to the hdeAB acid stress operon. We extracted HdeB from bacteria by the osmotic-shock procedure and purified it to homogeneity by ionexchange chromatography ...

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