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SOP - Scholarly Publications: Recent submissions

  • Herbal Products and Dietary Supplements 
    El Khoury, Ghada; Ramadan, Wijdan; Zeeni, Nadine; SOP; SAS; 200104046; 199312180; 201000400; N/A; ghada.khoury@lau.edu.lb; wramadan@lau.edu.lb; nadine.zeeni@lau.edu.lb
    There has been a marked increase in use of herbal products and dietary supplements (HP/DS) in many developed and developing countries. However, data about consumption patterns and awareness about these products in the ...
  • Influenza Vaccination 
    El Khoury, Ghada; SOP; 200104046; N/A; ghada.khoury@lau.edu.lb
    Background: Influenza is a common preventable infectious disease associated with high mortality and morbidity. Vaccination is the most cost-effective measure to prevent influenza, yet the vaccine uptake is known to be low. ...
  • Optimizing clopidogrel dose response 
    Saab, Yolande B.; Zeenny, Rony; Ramadan, Wijdan H.; SOP; 199110360; N/A; ysaab@lau.edu.lb
    Purpose Response to clopidogrel varies widely with nonresponse rates ranging from 4% to 30%. A reduced function of the gene variant of the CYP2C19 has been associated with lower drug metabolite levels, and hence diminished ...
  • Toll-like receptor stimulation of innate immunity triggers paradoxical suppression of CD8+ T-Cells 
    Abouantoun, T.; Eliott, ST; Blanco, FC; Miles, SA; SOP; 201005279; N/A; tamara.abouantoun@lau.edu.lb
  • Programming Effects of Short Prenatal Exposure to Dexamethasone in Sheep 
    Abouantoun, Tamara; Dodic, Miodrag; O'Connor, Anne; Wintour, E. Marelyn; Moritz, Karen M.; SOP; 201005279; N/A; tamara.abouantoun@lau.edu.lb
    Recent studies have linked fetal exposure to a suboptimal intrauterine environment with adult hypertension. The aims of the present study were to see whether prenatal dexamethasone administered intravenously to the ewe ...
  • Effects of Radiotherapy on the Risk of Developing Secondary Malignant Neoplasms in Hodgkin’s Lymphoma Survivors 
    Abou-Antoun, Tamara; Mikheal, Rachelle; Massoud, Marcel; Chahine, Georges; Saade, Aline; SOP; 201005279; 200703818; N/A; tamara.abouantoun@lau.edu.lb; aline.saad@lau.edu.lb
    Extended follow-up of Hodgkin lymphoma (HL) survivors indicates that these patients are at high risk of secondary malignant neoplasms (SMNs) contributing to increased morbidity and mortality. This study examined the ...
  • Proteomic analysis of treatment-resistant, stem-like cancer cells. 
    Abou-Antoun, Tamara J.; Saab, Bassem E.; Nazarian, Javad; Sandler, Anthony; SOP; 201005279; N/A; tamara.abouantoun@lau.edu.lb
    Valid data supports the cancer stem cell theory for solid tumors and it appears that tumor cells responsible for failure after successful initial therapy exhibit stem cell properties, including self-renewal, potent tumorigenic ...
  • New GABAergic interneurons in the adult neocortex and striatum are generated from different precursors 
    Dayer, Alexandre G.; Cleaver, Kathryn M.; Abouantoun, Thamara; Camerin, Heather A.; SOP; 201005279; N/A; tamara.abouantoun@lau.edu.lb
    Ongoing neurogenesis in the adult mammalian dentate gyrus and olfactory bulb is generally accepted, but its existence in other adult brain regions is highly controversial. We labeled newly born cells in adult rats with the ...
  • Imatinib blocks migration and invasion of medulloblastoma cells by concurrently inhibiting activation of platelet-derived growth factor receptor and transactivation of epidermal growth factor receptor 
    Abouantoun, Thamara J.; MacDonald, Tobey J.; SOP; 201005279; N/A; tamara.abouantoun@lau.edu.lb
    Platelet-derived growth factor (PDGF) receptor (PDGFR) expression correlates with metastatic medulloblastoma. PDGF stimulation of medulloblastoma cells phosphorylates extracellular signal-regulated kinase (ERK) and promotes ...
  • Sunitinib induces PTEN expression and inhibits PDGFR signaling and migration of medulloblastoma cells 
    Castellino, R.C.; MacDonald, T.J.; Abouantoun, Thamara J.; SOP; 201005279; N/A; tamara.abouantoun@lau.edu.lb
    We previously showed that inhibition of the platelet-derived growth factor receptor (PDGFR) blocks the survival and migration of medulloblastoma cells. Identification of in vitro PDGFR-targeting pharmacologic agents that ...
  • Reversible adaptive plasticity 
    Abou-Antoun, Thamara; Chakrabati, Lina; Vykmanovic, Stainslav; Sandler, Anthony D.; SOP; 201005279; N/A; tamara.abouantoun@lau.edu.lb
    We describe a novel form of tumor cell plasticity characterized by reversible adaptive plasticity in murine and human neuroblastoma. Two cellular phenotypes were defined by their ability to exhibit adhered, anchorage ...
  • Elevated Heparin-Induced Antibodies Are More Common in Diabetic Patients with Vascular Disease 
    Naoum, Joseph J.; Chamoun, Nibal R.; Patel, Mitul S.; Street, Tiffany; Haydar, Mazen; Bismuth, Jean; El-Sayed, Hosam F.; Davies, Mark G.; Lumsden, Alan B.; Peden, Eric K.; SOP; 200201071; N/A; nibal.chamoun@lau.edu.lb
    Background. Hypercoagulable disorders can lead to deep vein thrombosis (DVT), arterial thrombosis or embolization, and early or recurrent bypass graft failure. The purpose of this study was to identify whether diabetes ...
  • The association of hypertension with renin–angiotensin system gene polymorphisms in the Lebanese population 
    Saab, YB; Gard, PR; Overall, ADJ; SOP; 199110360; N/A; ysaab@lau.edu.lb
    Aim: The study objective was to examine the association of hypertension in the Lebanese population with three renin–angiotensin system gene polymorphisms (RAS): angiotensin-converting enzyme (ACE), angiotensinogen (AGT) ...
  • Genetic Polymorphisms of CYP2C9 
    Saab, Yolande B.; Langace, Taimour; SOP; 199110360; N/A; ysaab@lau.edu.lb
    Background: There is little knowledge about genotyping of cytochrome P450s in the Middle East, and there has not been any report on the genotype of CYP2C9 allelic variants in Lebanese population . Aims and objectives: The ...
  • Renin–angiotensin-system gene polymorphisms and depression 
    Saab, Yolande B.; Gard, Paul R.; Yeoman, Mark S.; Mfarref, Bechara; El-Moalen, Bechara; SOP; 199110360; N/A; ysaab@lau.edu.lb
    Given the abundance of the renin–angiotensin system (RAS) components in the brain, their importance in behavior and cognition, and the data that implicates them in the etiology and treatment of depression, it is possible ...
  • Cytochrome P450 2D6 polymorphism in white Lebanese population 
    Saab, Yolande; Saade, Sarita; Mroueh, Mohamad; SOP; 199110360; 199590020; N/A; ysaab@lau.edu.lb; mmroueh@lau.edu.lb
    Objective: Genetic, environmental, physiological and pathophysiological factors contribute to the interindividual variability in drug metabolism and response. Among the different cytochromes responsible for drug disposition, ...
  • Attitudes of Physicians to Professional Roles of Community Pharmacists in Lebanon 
    Saab, Yolande B.; Hachem, Ayla H.; SOP; 199110360; N/A; ysaab@lau.edu.lb
    Background: Pharmacists involved in patient-centred clinical services can potentially reduce overall healthcare costs, morbidity and mortality. However, physicians might be ambivalent about pharmacists' capabilities. Aim: ...
  • Spiramycin-induced liver injury 
    Saab, YB; Mroueh, MA; SOP; 199110360; N/A; ysaab@lau.edu.lb
  • Pharmacy education in Lebanon 
    Saab, Yolande B.; Khachan, Victor; Sadik, Farid; SOP; 199110360; N/A; ysaab@lau.edu.lb
    Objective Challenges faced by academia are no longer shaped by information accessibility but rather, and perhaps surprisingly so, by availability. A case in point is the lack of information on pharmacy education in ...
  • Hepatoprotective activity of Centaurium erythraea on acetaminophen-induced hepatotoxicity in rats 
    Saab, Yolande; Mroueh, Mohamad; Rizkallah, Raed; SOP; 199110360; N/A; ysaab@lau.edu.lb
    The methanol extract of the leaves of Centaurium erythraea L. (Gentianaceae) was evaluated for hepatoprotective activity against acetaminophen-induced liver toxicity in rats. An oral dose of 300 mg/kg/day for 6 days or a ...

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