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SoAS - Scholarly Publications: Recent submissions

  • Mutational landscape of aggressive cutaneous squamous cell carcinoma 
    Saade, Rami E.; Pickering, Curtis R.; Zhou, Jane H.; Drummond, Jennifer A.; Curry, Jonathan; SAS; 200102768; Natural Sciences; rami.saade@lau.edu.lb; Lebanese American University
    Purpose: Aggressive cutaneous squamous cell carcinoma (cSCC) is often a disfiguring and lethal disease. Very little is currently known about the mutations that drive aggressive cSCC. Experimental Design: Whole exome ...
  • Angiotensin II AT1 receptor internalization, translocation and de novo synthesis modulate cytosolic and nuclear calcium in human vascular smooth muscle cells 
    Sleiman, S.; Bkaily, G.; Stephan, J.; Asselin, C.; Choufani, S.; Kamal, M.; Jacques, D.; Gobeil, F.; D'Orleans-Juste, P.; SAS; 201408170; Natural Sciences; sama.sleiman@lau.edu.lb; Lebanese American University
    The present study was designed to verify if human (h) Angiotensin II (Ang II) type-1 receptor (hAT1R) undergoes internalization, nuclear translocation, and de novo synthesis in primary culture of human aortic vascular ...
  • Alteration of the DNA binding domain disrupts distinct functions of the C. elegans Pax protein EGL-38 
    Sleiman, Sama F.; Zhang, Guojuan; Tseng, Ronj-Jeng; Rajakumar, Vandana; Wang, Xiadong; Chamberlin, Helen M.; SAS; 201408170; Natural Sciences; sama.sleiman@lau.edu.lb; Lebanese American University
    The paired-domain-containing Pax transcription factors play an important role in the development of a range of organ, tissue and cell types. Although DNA binding elements and target genes for Pax proteins have been identified, ...
  • Modulation of caenorhabditis elegans transcription factor activity by HIM-8 and the related zinc-finger ZIM proteins 
    Sleiman, Sama F.; Sun, Hongliu; Nehms, Brian L.; Chamberlin, Helen M.; Hanna-Rose, Wendy; SAS; 201408170; Natural Sciences; sama.sleiman@lau.edu.lb; Lebanese American University
    The previously reported negative regulatory activity of HIM-8 on the Sox protein EGL-13 is shared by the HIM-8-related ZIM proteins. Furthermore, mutation of HIM-8 can modulate the effects of substitution mutations in the ...
  • Putting the ‘HAT’ back on survival signalling 
    Sleiman, Sama F.; Basso, Manuela; Mashishi, Lata; Kozikowski, Alan P.; Donohoe, Mary E.; Langley, Brett; Ratan, Rajiv R.; SAS; 201408170; Natural Sciences; sama.sleiman@lau.edu.lb; Lebanese American University
    Decreased histone acetyltransferase activity and transcriptional dysfunction have been implicated in almost all neurodegenerative conditions. Increasing net histone acetyltransferase activity through inhibition of the ...
  • Inhibition of transglutaminase 2 mitigates transcriptional dysregulation in models of Huntington disease 
    Sleiman, Sama F.; Mashishi, Lata; Coppola, Giovanni; Thompson, Leslie M.; Ratan, Rajiv R.; Starkov, Anatoly; Antonyak, Marc A.; SAS; 201408170; Natural Sciences; sama.sleiman@lau.edu.lb; Lebanese American University
    Caused by a polyglutamine expansion in the huntingtin protein, Huntington's disease leads to striatal degeneration via the transcriptional dysregulation of a number of genes, including those involved in mitochondrial ...
  • Mithramycin is a gene-selective Sp1 inhibitor that identifies a biological intersection between cancer and neurodegeneration 
    Sleiman, Sama F.; Langley, Brett C.; Berlin, Jill; Xia, Li; Payappilly, Jimmy B.; Kharel, Madan K.; Guo, Hengchang; Thonpson, Leslie Michels; Mahishi, Lata; Ahuja, Preeti; Maclellan, W. Robb; Geschwind, Daniel H.; Coppola, Giovanni; Rohr, Jurgen; Ratan, Rajiv R.; SAS; 201408170; Natural Sciences; sama.sleiman@lau.edu.lb; Lebanese American University
    Oncogenic transformation of postmitotic neurons triggers cell death, but the identity of genes critical for degeneration remain unclear. The antitumor antibiotic mithramycin prolongs survival of mouse models of Huntington's ...
  • Histone deacetylase inhibitors and mithramycin a impact a similar neuroprotective pathway at a crossroad between cancer and neurodegeneration 
    Sleiman, Sama F.; Berlin, Jill; Basso, Manuela; Karuppagounder, Saravanan S.; Rohr, Jurgen; Ratan, Rajiv R.; SAS; 201408170; Natural Sciences; sama.sleiman@lau.edu.lb; Lebanese American University
    Mithramycin A (MTM) and histone deacetylase inhibitors (HDACi) are effective therapeutic agents for cancer and neurodegenerative diseases. MTM is a FDA approved aureolic acid-type antibiotic that binds to GC-rich DNA ...
  • Developmental functions for the Caenorhabditis elegans Sp protein SPTF-3 
    Sleiman, Sama F.; Ulm, Elizabeth A.; Chamberlin, Helen M.; SAS; 201408170; Natural Sciences; sama.sleiman@lau.edu.lb; Lebanese American University
    Sp factors are important for animal development and the transcriptional regulation of a wide variety of genes. How they influence the developmental decisions of individual cells within the organism, however, is poorly ...
  • Transglutaminase inhibition protects against oxidative stress-induced neuronal death downstream of pathological ERK activation 
    Sleiman, Sama F.; Basso, Manuela; Xia, Li; Berlin, Jill; Ko, Brendan; Haskew-Layton, Renee; Kim, Eunhee; Antonyak, Marc A.; Cerione, Richard A.; Lismaa, Siri E.; Willis, Dianna; Cho, Sunghee; Ratan, Rajiv R.; SAS; 201408170; Natural Sciences; sama.sleiman@lau.edu.lb; Lebanese American University
    Molecular deletion of transglutaminase 2 (TG2) has been shown to improve function and survival in a host of neurological conditions including stroke, Huntington's disease, and Parkinson's disease. However, unifying schemes ...
  • In vitro ischemia suppresses hypoxic induction of hypoxia-inducible factor-1α by inhibition of synthesis and not enhanced degradation 
    Sleiman, Sama F.; SAS; 201408170; Natural Sciences; sama.sleiman@lau.edu.lb; Lebanese American University
    Hypoxia-inducible factor (HIF) mediates a broad, conserved adaptive response to hypoxia, and the HIF pathway is a potential therapeutic target in cerebral ischemia. This study investigated the mechanism by which in vitro ...
  • Hypoxia-inducible factor prolyl hydroxylases as targets for neuroprotection by “antioxidant” metal chelators 
    Sleiman, Sama F.; Speer, Rachel E.; Karuppagounder, Savaranan S.; Basso, Manuela; Kumar, Amit; Brand, David; Smirnova, Natalya; Gazaryan, Irina; Khim, Soah J.; SAS; 201408170; Natural Sciences; sama.sleiman@lau.edu.lb; Lebanese American University
    Neurologic conditions including stroke, Alzheimer disease, Parkinson disease, and Huntington disease are leading causes of death and long-term disability in the United States, and efforts to develop novel therapeutics for ...
  • Epigenetics of Alzheimer’s disease and frontotemporal dementia 
    Sleiman, Sama; Veerappan, Chendhore S.; Coppola, Giovanni; SAS; 201408170; Natural Sciences; sama.sleiman@lau.edu.lb; Lebanese American University
    This article will review the recent advances in the understanding of the role of epigenetic modifications and the promise of future epigenetic therapy in neurodegenerative dementias, including Alzheimer’s disease and ...
  • Looking above but not beyond the genome for therapeutics in neurology and psychiatry 
    Sleiman, Sama; Ratan, Rajiv R.; Basso, Manuela; SAS; 201408170; Natural Sciences; sama.sleiman@lau.edu.lb; Lebanese American University
    We welcome you to a special issue of Neurotherapeutics that highlights much of the exciting new thinking behind a burgeoning and therapeutically relevant topic—epigenetic proteins in psychiatric and neurological disease. ...
  • Antihelminthic benzimidazoles are novel HIF activators that prevent oxidative neuronal death via binding to tubulin 
    Sleiman, Sama; Aleyasin, Hossein; Karuppagounder, Saravanan S.; Kumar, Amit; Basso, Manuela; Ma, Thong; Siddiq, Ambreena; SAS; 201408170; Natural Sciences; sama.sleiman@lau.edu.lb; Lebanese American University
    Aims: Pharmacological activation of the adaptive response to hypoxia is a therapeutic strategy of growing interest for neurological conditions, including stroke, Huntington's disease, and Parkinson's disease. We screened ...
  • Hydroxamic acid-based histone deacetylase (HDAC) inhibitors can mediate neuroprotection independent of HDAC inhibition 
    Sleiman, Sama F.; SAS; 201408170; Natural Sciences; sama.sleiman@lau.edu.lb; Lebanese American University
    Histone deacetylase (HDAC) inhibition improves function and extends survival in rodent models of a host of neurological conditions, including stroke, and neurodegenerative diseases. Our understanding, however, of the ...
  • Studying Students across Borders 
    Kreidieh, S.; Click, A.; Stopel, M.; Alam, M. T.; Flanagan, D.; Foster, N. F.; N/A; 197401890; N/A; skrdieh@lau.edu.lb; Lebanese American University
    Librarians often feel that we understand the needs of our undergraduate users. Isn’t it possible, however, that we make incorrect assumptions based on our perception of these learners? In 2009, representatives from four ...
  • 6th International Conference on Enterprise Information Systems 
    Haraty, Ramzi A.; El-Kassar, A. N.; Otrok, Hadi; SOB; SAS; 199529190; 199729410; Department of Information Technology and Operations Management (ITOM); abdulnasser.kassar@lau.edu.lb; rharaty@lau.edu.lb; Lebanese American University (INSTICC, )
    In 1985 a powerful and practical public-key scheme was produced by ElGamal; his work was applied using large prime integers. El-Kassar et al. and El-Kassar and Haraty modified the ElGamal public-key encryption scheme from ...
  • IEEE/WIC/ACM International Conference on Intelligent Agent Technology 
    Khazen, Georges; Riachi, Imad; Mouawad, Mounir; Abou-Naccoul, Nada; Artail, Hassan; SAS; 201105253; Computer Science and Mathematics; GKhazen@lau.edu.lb; Lebanese American University (IEEE Computer SocietyLos Alamitos, Calif., )
    In this paper we are proposing a new distributed system architecture to address the problem of very large scale sensor network monitoring. By dynamically aggregating and processing data from sensor networks, databases and ...
  • Reconstruction and simulation of neocortical microcircuitry 
    Khazen, Georges; Markram, Henry; Muller, Eilif; Ramaswamy, Srikanth; Reimann, Michael W.; Abdellah, Marwan; Sanchez, Carlos Aguado; SAS; 201105253; Computer Science and Mathematics; gkhazen@lau.edu.lb; Lebanese American University
    We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed ...

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