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SoAS - Scholarly Publications: Recent submissions

  • Palladin regulation of the actin structures needed for cancer invasion 
    El-Sibai, Mirvat; Najm, Paul; SAS; 200703859; Natural Sciences; mirvat.elsibai@lau.edu.lb (2015-12-17)
    Cell migration and invasion involve the formation of cell adhesion structures as well as the dynamic and spatial regulation of the cytoskeleton. The adhesive structures known as podosomes and invadopodia share a common ...
  • Signaling networks of Rho GTPases in cell motility 
    El-Sibai, Mirvat; Hanna, Samer; SAS; 200703859; Natural Sciences; mirvat.elsibai@lau.edu.lb (2015-12-17)
    The last decades have witnessed an exponential increase in our knowledge of Rho GTPase signaling network which further highlighted the cross talk between these proteins and the complexity of their signaling pathways. In ...
  • The STAR of the DLC family 
    El-Sibai, Mirvat; El-Sitt, Sally; SAS; 200703859; Natural Sciences; mirvat.elsibai@lau.edu.lb (2015-12-17)
    RhoGTPases are defined as a family of 20 small G proteins playing important roles in almost every cellular process. RhoGTPases are guanine nucleotide-binding proteins existing in two forms: the active form which is GTP ...
  • ALOX5AP gene variants show differential association with coronary artery disease in different populations 
    El-Sibai, Mirvat; Deeb, Mary E.; Khazen, Georges; Zreik, Tony G.; El Bayeh, Hamid; Zalloua, Pierre A.; Alwan, Ahmad; Platt, Daniel E.; Saade, Stephanie; Youhanna, Sonia C.; Maalouf, Assaad; Abchee, Antoine; SAS; SOP; SOM; 200703859; 200900035; 201105253; 200802707; 200902679; 200300001; Natural Sciences; mirvat.elsibai@lau.edu.lb; mary.deeb@lau.edu.lb; GKhazen@lau.edu.lb; tgzreik@lau.edu.lb; hamid.elbayeh@lau.edu.lb; pierre.zalloua@lau.edu.lb (2015-12-17)
    Coronary artery disease (CAD) is a complex disease with various components, genetic as well as environmental. Previous reports correlating ALOX5AP gene variants and CAD showed conflicting results depending on the population ...
  • Influences of history, geography, and religion on genetic structure 
    El-Sibai, Mirvat; Zalloua, Pierre A.; Platt, Daniel E.; Badro, Danielle; Xue, Yali; Haber, Marc; Ashrafian Bonab, Maziar; Youhanna, Sonia C.; Saade, Stephanie; Soria-Hernanz, David; Spencer Wells, R; Tyler-Smith, Chris; Royyuru, Ajay; SAS; 200703859; 200300001; Natural Sciences; mirvat.elsibai@lau.edu.lb; pierre.zalloua@lau.edu.lb (2015-12-17)
    Cultural expansions, including of religions, frequently leave genetic traces of differentiation and in-migration. These expansions may be driven by complex doctrinal differentiation, together with major population migrations ...
  • The I allele of the angiotensin converting enzyme I/D polymorphism confers protection against coronary artery disease 
    El-Sibai, Mirvat; Zreik, Tony G.; Zalloua, Pierre A.; Abchee, Antoine; Youhanna, Sonia; Makhoul, Nadine; Puzantian, Houry; Sawaya, Jaber; Nasrallah, Antoine; Abdallah, Rebeiz; Yerezian, Joumana; Azar, Sami; Hanine, Estephan; SAS; 200703859; 200802707; 200300001; Natural Sciences; mirvat.elsibai@lau.edu.lb; tgzreik@lau.edu.lb; pierre.zalloua@lau.edu.lb (2015-12-17)
    Background: Mutations in genes regulating lipid metabolism, vasoactivity, and coagulation are important modulators of coronary artery disease (CAD). Objective: This study investigated the association between allelic ...
  • IL-1 stimulates ceramide accumulation without inducing apoptosis in intestinal epithelial cells 
    El-Sibai, Mirvat; Homaidan, Fadia R.; El-Sabban, Marwan E.; Chakroun, Iman; Dbaibo, Ghassan S.; SAS; 200703859; Natural Sciences; mirvat.elsibai@lau.edu.lb (2015-12-17)
    Background: In inflammatory bowel disease (IBD), cytokine levels (such as interleukin-1 (IL-1)) are elevated. We have shown previously that IL-1 activates phospholipid signaling pathways in intestinal epithelial cells ...
  • Daucus carota pentane-based fractions arrest the cell cycle and increase apoptosis in MDA-MB-231 breast cancer cells 
    Mroueh, Mohammad; Taleb, Robin I.; Daher, Costantine F.; El-Sibai, Mirvat; Shebaby, Wassim N.; Bodman-Smith, Kikki; Mansour, Anthony; SAS; SOP; 199590020; 200901968; 199190130; 200703859; Natural Sciences; mmroueh@lau.edu.lb; robin.taleb@lau.edu.lb; cdaher@lau.edu.lb; mirvat.elsibai@lau.edu.lb (2015-12-16)
    Background Daucus carota L.ssp.carota (wild carrot), an herb used in folk medicine worldwide, was recently demonstrated to exhibit anticancer activity. In this study we examined the anticancer effect of Daucus carota oil ...
  • Hepatoprotective, Antioxidant, and Anticancer Effects of the Tragopogon porrifolius Methanolic Extract 
    El-Sibai, Mirvat; Daher, Costantine F.; Mroueh, Mohamad; Tenkerian, Clara; SAS; SOP; 200703859; 199190130; 199590020; Natural Sciences; mirvat.elsibai@lau.edu.lb; cdaher@lau.edu.lb; mmroueh@lau.edu.lb (2015-12-16)
    Tragopogon porrifolius (Asteraceae), commonly referred to as white salsify, is an edible herb used in Lebanese folk medicine to treat cancer and liver dysfunction. In this study, we investigated the antioxidant activity ...
  • Environmental enrichment and cafeteria diet attenuate the response to chronic variable stress in rats 
    Zeeni, N.; Bassil, M.; Daher, C. F.; Fromentin, G.; Chaumontet, C.; Darcel, N.; Tome, D.; SAS; 199190130; 201000400; 199190130; Natural Sciences; nadine.zeeni@lau.edu.lb; mbassil@lau.edu.lb; cdaher@lau.edu.lb (2015-12-16)
    Exposure to an enriched environment (EE) or the intake of a highly palatable diet may reduce the response to chronic stress in rodents. To further explore the relationships between EE, dietary intake and stress, male ...
  • Effect of a surfactant, Tween 80, on the formation and secretion of chylomicrons in the rat 
    Daher, C. F.; Baroody, G. M.; Howland, R. J.; SAS; 199190130; Natural Sciences; cdaher@lau.edu.lb (2015-12-16)
    Effects of Tween 80, a nonionic surfactant, on size and number of chylomicrons (CM) secreted during lipid absorption in the rat model are reported. Fasted rats were loaded with either 154 mm NaCl or 25% (w/w) olive oil ...
  • Antioxidant and hepatoprotective activities of the oil fractions from wild carrot (Daucus carota ssp. carota) 
    Daher, Costantine F.; El-Sibai, Mirvat; Mroueh, Mohamad; Shebaby, Wassim N.; Bodman-Smith, Kikki; Mansour, Anthony; Karam, Marc C.; SAS; SOP; 199190130; 200703859; 199590020; Natural Sciences; cdaher@lau.edu.lb; mirvat.elsibai@lau.edu.lb; mmroueh@lau.edu.lb (2015-12-16)
    Context: Wild carrot, Daucus carota L. ssp. carota (Apiacae), is widely distributed throughout the world and has various uses in traditional medicine in Lebanon. Objective: The present study aimed to fractionate and ...
  • Magnetic property, DFT calculation, and biological activity of bis[(μ2-chloro)chloro(1,10-phenanthroline)copper(II)] complex 
    Mroueh, Mohamad; Daher, Costantine; Hariri, Essa; Demirdjian, Sally; Isber, Samih; Choi, Eun Sang; Mirtamizdoust, Babak; Hammud, Hassan H.; SAS; SOP; 199190130; 199590020; Natural Sciences; mmroueh@lau.edu.lb; cdaher@lau.edu.lb (2015-12-16)
    The dinuclear complex bis[(μ2-chloro)chloro(1,10-phenanthroline)copper(II)] (1) was synthesized, and characterized by X-ray, FTIR and thermal analysis. The fitting of magnetic susceptibility and magnetization curve of (1) ...
  • Effect of theophylline on l-alanine absorption in the rat jejunum 
    Daher, Costantine F.; Khoury, Carmen I.; Nassar, Camille; SAS; 199190130; Natural Sciences; cdaher@lau.edu.lb (2015-12-16)
    The effect of theophylline on the accumulation of l-alanine (Ala) by the rat jejunum and the mechanism involved has been investigated. Ala is rapidly accumulated by the jejunal strips in vitro and saturation is reached ...
  • The modulatory effect of leptin on the overall insulin production in ex-vivo normal rat pancreas 
    Daher, C.; Haddad, N.; Howland, R.; Baroody, G.; SAS; 199190130; Natural Sciences; cdaher@lau.edu.lb (2015-12-16)
    Leptin has a modulator effect on glucose-stimulated insulin secretion. To define the influences of different glucose (4, 8, 12, and 16 mmol/L) and leptin (5, 10, 15, and 20 nmol/L) concentrations on total insulin release ...
  • Tragopogon porrifolius improves serum lipid profile and increases short-term satiety in rats 
    Zeeni, Nadine; Daher, Costantine F.; Mroueh, Mohamad; Saab, Lea; SAS; 199190130; 201000400; 199590020; Natural Sciences; nadine.zeeni@lau.edu.lb; cdaher@lau.edu.lb; mmroueh@lau.edu.lb (2015-12-15)
    Tragopogon porrifolius (white salsify) is an edible plant commonly used in folk medicine in Lebanon and neighbouring countries. This study investigates the effect of the aqueous extract of the aerial part of T. porrifolius ...
  • A cafeteria diet modifies the response to chronic variable stress in rats 
    Zeeni, N.; Daher, C.; Formentin, G.; Tome, D.; Darcel, N.; Chaumontet, C.; SAS; 201000400; 199190130; Natural Sciences; nadine.zeeni@lau.edu.lb; cdaher@lau.edu.lb (2015-12-15)
    Stress is known to lead to metabolic and behavioral changes. To study the possible relationships between stress and dietary intake, male Sprague-Dawley rats were fed one of three diets for 6 weeks: high carbohydrate (HC), ...
  • Glycemic Index of commonly consumed Lebanese mixed meals and desserts 
    Daher, C. F.; Farhat, A. G.; Moukarzel, S. R.; El-Said, R. J.; SAS; 199190130; Natural Sciences; cdaher@lau.edu.lb (2015-12-15)
    The determination of the Glycemic Index (GI) and Load (GL) for mixed meals serves as a dietetic tool in meal planning to reinforce the benefits of low GI meals and decrease the physiological effects of high GI meals. In ...
  • Effect of acute and chronic moderate alcohol consumption on fasted and postprandial lipemia in the rat 
    Daher, Costantine F.; Berberi, Rania N.; Baroody, George M.; SAS; 199190130; Natural Sciences; cdaher@lau.edu.lb (2015-12-15)
    Effects of acute and chronic alcohol intake on fasted and postprandial lipemia in the rat model are reported. In the acute study, fasted rats are loaded with a 30% w/w olive oil emulsion with or without 8% alcohol in the ...
  • Effect of acute and chronic grapefruit, orange, and pineapple juice intake on blood lipid profile in normolipidemic rat. 
    Daher, Costantine F.; Abou-Khalil, Jamil; Baroody, George; SAS; 199190130; Natural Sciences; cdaher@lau.edu.lb (2015-12-15)
    Background: High fruit intake is known to be associated with reduced riskof coronary heart disease. Our objective was to determine the effects of acute and chronic juice [grapefruit,orange, and pineapple] intake on plasma ...

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