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SoAS - Scholarly Publications: Recent submissions

  • Natural Killer Cell Immunoglobulin-like Receptor (KIR) genotypes in Follicular Lymphoma patients 
    Khalaf, Roy; Hoteit, Rouba; Yazbek, Soha; El Hajj, Nady; Otrock, Zaher; Khansa, Sarah; Sabbagh, Amira; Shammaa, Dina; Mahfouz, Rami; SAS; 200300427; Natural Sciences; roy.khalaf@lau.edu.lb (2016-03-21)
    Aims The Natural Killer Cell Immunoglobulin-like Receptor (KIR) genotype profiling in Follicular Lymphoma has not been reported before in the literature. Materials and methods DNA extracted from 20 Follicular ...
  • The Candida albicans Hwp2p can complement the lack of filamentation of a Saccharomyces cerevisiae flo11 null strain 
    Khalaf, Roy A.; Younes, Samer; SAS; 200300427; Natural Sciences; roy.khalaf@lau.edu.lb (2016-03-18)
    The opportunistic fungal pathogen Candida albicans is one of the leading agents of life-threatening infections affecting immunocompromised individuals. Many factors make C. albicans a successful pathogen. These include the ...
  • Deletion of the Candida albicans PIR32 Results in Increased Virulence, Stress Response, and Upregulation of Cell Wall Chitin Deposition 
    El-Sibai, Mirvat; Khalaf, Roy A.; Abi Rizk, Marybel; Khalil, Bassem; Bahnan, Wael; El Sitt, Sally; Hanna, Samer; Younes, Samer; Koussa, Joseph; SAS; 200703859; 200300427; Natural Sciences; mirvat.elsibai@lau.edu.lb; roy.khalaf@lau.edu.lb (2016-03-18)
    Candida albicans is a common opportunistic pathogen that causes a wide variety of diseases in a human immunocompromised host leading to death. In a pathogen, cell wall proteins are important for stability as well as for ...
  • Nitrogen metabolism and virulence of Candida albicans require the GATA-type transcriptional activator encoded by GAT1 
    Khalaf, Roy A.; Limjindaporn, Thawornchai; Fonzi, William A.; SAS; 200300427; Natural Sciences; roy.khalaf@lau.edu.lb (2016-03-18)
    Nitrogen acquisition and metabolism is central to microbial growth. A conserved family of zinc-finger containing transcriptional regulators known as GATA-factors ensures efficient utilization of available nitrogen sources ...
  • The DNA Binding Protein Rfg1 Is a Repressor of Filamentation in Candida albicans 
    Khalaf, Roy A.; Zitomer, Richard S.; SAS; 200300427; Natural Sciences; roy.khalaf@lau.edu.lb (2016-03-18)
    We have identified a repressor of hyphal growth in the pathogenic yeast Candida albicans. The gene was originally cloned in an attempt to characterize the homologue of the Saccharomyces cerevisiae Rox1, a repressor of ...
  • Characterization of the DNA binding and bending HMG domain of the yeast hypoxic repressor Rox1 
    Khalaf, Roy A.; Deckert, Jutta; Hwang, Soo-Myung; Zitomer, Richard S.; SAS; 200300427; Natural Sciences; roy.khalaf@lau.edu.lb (2016-03-18)
    The yeast Rox1 hypoxic transcriptional repressor protein binds to and bends a specific DNA sequence through an HMG domain located at the N-terminus. To better understand the structure of Rox1 and how it interacts with DNA, ...
  • Distribution of Killer Cell Immunoglobulin–like Receptor (KIR) Genotypes in Patients with Familial Mediterranean Fever 
    Khazen, Georges; Khalaf, Roy A.; Mahfouz, Rami A.R.; Sabbagh, Amira S.; Shamseddine, Wael; Bazarbachi, Ali; SAS; 201105253; 200300427; Computer Science and Mathematics; GKhazen@lau.edu.lb; roy.khalaf@lau.edu.lb (2016-03-17)
    Genotypic profiles of the natural killer cell immunoglobulin–like receptors (KIR) have been reported to vary among different ethnic groups and variable clinical entities. This study represents the first report on its ...
  • Channelpedia 
    Khazen, Georges; Ranjan, Rajnish; Gambazzi, Luca; Ramaswamy, Srikanth; Markram, Henry; Hill, Sean L.; Schürmann, Felix; SAS; 201105253; Computer Science and Mathematics; GKhazen@lau.edu.lb (2016-03-17)
    Ion channels are membrane proteins that selectively conduct ions across the cell membrane. The flux of ions through ion channels drives electrical and biochemical processes in cells and plays a critical role in shaping ...
  • Combinatorial Expression Rules of Ion Channel Genes in Juvenile Rat (Rattus norvegicus) Neocortical Neurons 
    Khazen, Georges; Hill, Sean L.; Schurmann, Felix; Markram, Henry; SAS; 201105253; Computer Science and Mathematics; GKhazen@lau.edu.lb (2016-03-17)
    The electrical diversity of neurons arises from the expression of different combinations of ion channels. The gene expression rules governing these combinations are not known. We examined the expression of twenty-six ion ...
  • Large Scale Association Analysis Identifies Three Susceptibility Loci for Coronary Artery Disease 
    El-Khazen, Georges; Zalloua, Pierre A.; Saade, Stephanie; Cazier, Jean-Baptiste; Ghassibe-Sabbagh, Michella; Youhanna, Sonia; Badro, Danielle A.; Kamatani, Yoichiro; SAS; 201105253; 200300001; Computer Science and Mathematics; GKhazen@lau.edu.lb; pierre.zalloua@lau.edu.lb (2016-03-17)
    Genome wide association studies (GWAS) and their replications that have associated DNA variants with myocardial infarction (MI) and/or coronary artery disease (CAD) are predominantly based on populations of European or ...
  • Natural Killer Cell Immunoglobulin-like Receptors (KIR) Genotypes in two Arab Populations 
    Khazen, Georges; Rayes, Roni; Bazarbachi, Ali; Sabbagh, Amira; Zaatari, Ghazi; Mahfouz, Rami; SAS; 201105253; Computer Science and Mathematics; GKhazen@lau.edu.lb (2016-03-17)
    Genotypic profiles of the Natural killer cell Immunoglobulin-like Receptors (KIR) have been reported to vary among different ethnic groups and this study represents a comparative report on its distribution between two ...
  • Genome-Wide Association Study in a Lebanese Cohort Confirms PHACTR1 as a Major Determinant of Coronary Artery Stenosis 
    Khazen, Georges; Zalloua, Pierre A.; Hager, Jörg; Kamatani, Yoichiro; Cazier, Jean-Baptiste; Youhanna, Sonia; Ghassibe-Sabbagh, Michella; Platt, Daniel E.; SAS; 201105253; 200300001; Computer Science and Mathematics; GKhazen@lau.edu.lb; pierre.zalloua@lau.edu.lb (2016-03-17)
    The manifestation of coronary artery disease (CAD) follows a well-choreographed series of events that includes damage of arterial endothelial cells and deposition of lipids in the sub-endothelial layers. Genome-wide ...
  • Y-Chromosome and mtDNA Genetics Reveal Significant Contrasts in Affinities of Modern Middle Eastern Populations with European and African Populations 
    Khazen, Georges; Zalloua, Pierre A.; Badro, Danielle A.; Douaihy, Bouchra; Haber, Marc; Youhanna, Sonia C.; Salloum, Angélique; Ghassibe-Sabbagh, Michella; Johnsrud, Brian; SAS; 201105253; 200300001; Computer Science and Mathematics; GKhazen@lau.edu.lb; pierre.zalloua@lau.edu.lb (2016-03-17)
    The Middle East was a funnel of human expansion out of Africa, a staging area for the Neolithic Agricultural Revolution, and the home to some of the earliest world empires. Post LGM expansions into the region and subsequent ...
  • General developmental health in the VPA-rat model of autism 
    Khazen, Georges; Favre, Monica R.; Barakat, Tania R.; LaMendola, Deborah; Markram, Henry; Markram, Kamila; SAS; 201105253; Computer Science and Mathematics; GKhazen@lau.edu.lb (2016-03-17)
    Autism is a neurodevelopmental condition diagnosed by impaired social interaction, abnormal communication and, stereotyped behaviors. While post-mortem and imaging studies have provided good insights into the neurobiological ...
  • Investigating vulnerability for developing eating disorders in a multi-confessional population 
    Doumit, Rita; Khazen, Georges; Zeeni, Nadine; Kazandjian, Chant; Long, JoAnn; Katsounari, Ioanna; SAS; SON; 200200810; 201105253; 201000400; Computer Science and Mathematics; rita.doumit@lau.edu.lb; nadine.zeeni@lau.edu.lb; GKhazen@lau.edu.lb (2016-03-17)
    The present study aimed to examine the vulnerability to eating disorders (ED) among 949 Lebanese female young adults as well as its association with stress, anxiety, depression, body image dissatisfaction (BID), dysfunctional ...
  • Impact of inflammation, gene variants, and cigarette smoking on coronary artery disease risk 
    Kanbar, Roy; Zalloua, Pierre; Khazen, Georges; Demirdjian, Sally; Hariri, Essa; Sabbah, Nada; Youhanna, Sonia; Merhi, Mahmoud; SAS; 201005298; 200300001; 201105253; Computer Science and Mathematics; roy.kanbar@lau.edu.lb; pierre.zalloua@lau.edu.lb; GKhazen@lau.edu.lb (2016-03-17)
    Background The role of inflammation in coronary artery disease (CAD) pathogenesis is well recognized. Moreover, smoking inhalation increases the activity of inflammatory mediators through an increase in leukotriene synthesis ...
  • Cataract surgery outcomes at a UK independent sector treatment centre 
    Khazen, Georges; Syed, Zeba A.; Moayedi, Javad; Tashter, Jacob; Anthony, Teresa; Celiker, Celadet; Melki, Samir A.; SAS; 201105253; Computer Science and Mathematics; GKhazen@lau.edu.lb (2016-03-17)
    Background/Aims The goal of this study was to review cataract surgery outcomes at three independent surgery treatment centres established by the UK Specialist Hospitals (UKSH) and to compare these outcomes with recognised ...
  • Anxiety as a moderator of the relationship between body image and restrained eating 
    Doumit, Rita; Zeeni, Nadine; Sanchez-Ruiz, Maria-José; Khazen, Georges; SAS; SON; 200200810; 201000400; 201005175; 201105253; rita.doumit@lau.edu.lb; nadine.zeeni@lau.edu.lb; maria-jose.sanchez-ruiz@lau.edu.lb; GKhazen@lau.edu.lb (2016-03-17)
    Purpose To examine three indicators of psychopathology (stress, anxiety, and depression) as potential moderators of the relationship between body image dissatisfaction (BID) and restrained, emotional, and external eating, ...
  • Association of coronary artery disease and chronic kidney disease in Lebanese population 
    Milane, Aline; Khazen, Georges; Salloum, Angelique K.; Zalloua, Pierre; Ghassibe-Sabbagh, Michella; Zeineddine, Nabil; Masri, Leila; El Bayeh, Hamid; SAS; SOP; 200904164; 200703831; 201105253; Computer Science and Mathematics; aline.milane@lau.edu.lb; GKhazen@lau.edu.lb; angelique.salloum@lau.edu.lb; pierre.zalloua@lau.edu.lb (2016-03-17)
    Background: More evidence is emerging on the strong association between chronic kidney disease (CKD) and cardiovascular disease. We assessed the relationship between coronary artery disease (CAD) and renal dysfunction level ...
  • Heavy Metals Removal Using Activated Carbon, Silica and Silica Activated Carbon Composite 
    Kabbani, Ahmad; Karnib, Mona; Holail, Hanafy; Olama, Zakia; SAS; 198029470; Natural Sciences; akabbani@lau.edu.lb (2016-03-15)
    Heavy metal pollution has become one of the most serious environmental problems nowadays. The removal of heavy metals from the environment is of special concern due to their persistence. Batch experiments were conducted ...

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