School of Pharmacy: Recent submissions

Now showing items 81-100 of 335

Nonsuperoxide lucigenin-enhanced chemiluminescence from phospholipids and human saphenous veins

Capomacchia, Anthony C.; Barber, Dustan A.; Do, Ngoc H.; Tackett, Randall L.

The use of lucigenin-enhanced chemiluminescence (CL) for the detection of superoxide (O2·−) has grown in popularity due to an increased demand for a simple and specific system capable of measuring superoxide. In this study ...
Use of stop-flow oxalate ester chemiluminescence as a means to determine conditions for high-performance liquid chromatography chemiluminescence detection of retinoids using normal-phase chromatography

Capomacchia, Anthony C.; Bryant, Peter D.

Stop-flow chemiluminescence (CL) has been used to determine the conditions necessary for the oxalate ester CL detection of selected retinoids after separation by normal-phase HPLC. Also, the detection of the selected ...
Confirmation of iminoacridan structure of singly protonated 9-aminoacridine

Capomacchia, Anthony C.; Schulman, Stephen G.

The occurrence of the second absorption band of singly protonated 9-aminoacridine, which arises from an acridinium ring-localized transition, at anomalously short wavelength indicates the disruption of the aromaticity of ...
Electronic spectra and electronic structures of some antimicrobials derived from proflavine

Capomacchia, Anthony C.; Schulman, Stephen G.; Naik, Datta V.; Roy, Timothy

The shifts in the absorption and fluorescence spectra of 3-aminoacridine, proflavine, acridine orange, and acridine yellow were employed to show that the singly charged cations, the predominant species at biological pH, ...
Electronic absorption and fluorescence spectrophotometry of quinacrine

Capomacchia, Anthony C.; Schulman, Stephen G.; SOP; 201408778; Pharmaceutical Sciences Department; anthony.capomacchia@lau.edu.lb; Lebanese American University

The absorption and fluorescence spectra of quinacrine and its dealkylated derivative, 2-methoxy-6-chloro-9-aminoacridine, were studied as a function of pH and Hammett acidity. The relative stability and high quantum yield ...
Analysis of chlortetracycline by high performance liquid chromatography with postcolumn alkaline-induced fluorescence detection

Capomacchia, Anthony C.; Bryan, Peter D.; Hawkins, Kristina R.; Stewart, James T.; SOP; 201408778; Pharmaceutical Sciences Department; anthony.capomacchia@lau.edu.lb; Lebanese American University

A high performance liquid chromatographic method for the analysis of chlortetracycline (CTC) using postcolumn fluorescence detection has been developed. After chromatographic separation of CTC on a polystyrenedivinylbenzene ...
Valence tautomerism of singly protonated 9-aminoacridine and its implications for intercalative interactions with nucleic acids

Capomacchia, Anthony C.; Casper, Jay; Schulman, Stephen G.; SOP; 201408778; Pharmaceutical Sciences Department; anthony.capomacchia@lau.edu.lb; Lebanese American University

Electronic absorption and fluorescence spectroscopy were used to show that the singly protonated 9-aminoacridine cation exists as the vinylogous cyclic amidine valence tautomer, the 9-iminoacridan monocation, in ground and ...
Fluorescence of 6-methoxyquinoline, quinine, and quinidine in aqueous media

Capomacchia, Anthony C.; Threatte, Rose Marie; Schulman, Stephen C.; SOP; 201408778; Pharmaceutical Sciences Department; anthony.capomacchia@lau.edu.lb; Lebanese American University

The absorption and fluorescence spectra of 6-methoxy-quinoline, quinine, and quinidine were studied as a continuous function of pH. 6-Methoxyquinoline is a stronger base in the lowest excited singlet state, as reflected ...
Accelerated dissolution testing for controlled release microspheres using the flow-through dissolution apparatus

Capomacchia, A.C.; Collier, Jarrod W.; Thakare, Mohan; Ahmed, Hisham; Graner, Solomon T.; Israel, Bridgette; Granade, Saundra; SOP; 201408778; Pharmaceutical Sciences Department; anthony.capomacchia@lau.edu.lb; Lebanese American University

Theophylline controlled release capsules (THEO-24 CR) were used as a model system to evaluate accelerated dissolution tests for process and quality control and formulation development of controlled release formulations. ...
Physicochemical studies of binary eutectic of ibuprofen and ketoprofen for enhanced transdermal drug delivery

Capomacchia, Anthony Cesare; Yuan, Xudong; SOP; 201408778; Pharmaceutical Sciences Department; anthony.capomacchia@lau.edu.lb; Lebanese American University

Methods: The thermodynamic, eutectic, and crystalline properties of ibuprofen and ketoprofen binary mixtures were investigated using differential scanning calorimetry (DSC) and X-ray powder diffractometry (XRPD). Results: ...
Formulation parameters and release mechanism of theophylline loaded ethyl cellulose microspheres

Capomacchia, Anthony C.; Thakare, Mohan; Graner, Solomon T.; Ahmed, Hisham; Graner, Pamela; Elder, Deborah; Price, James C.; Israel, Bridgette; SOP; 201408778; Pharmaceutical Sciences Department; anthony.capomacchia@lau.edu.lb; Lebanese American University

Altering the combined hydrophilic-lipophilic balance (CHLB), by varying the ratio of dual surfactants, on formulation parameters and in vitro drug release of ethyl cellulose microspheres was examined. Theophylline, a ...
Influence of physicochemical properties on the in vitro skin permeation of the enantiomers, racemate, and eutectics of ibuprofen for enhanced transdermal drug delivery

Capomacchia, Anthony C.; Yuan, Xudong; SOP; 201408778; Pharmaceutical Sciences Department; anthony.capomacchia@lau.edu.lb; Lebanese American University

Physicochemical properties of chiral ibuprofen are significant to formulation scientists because its enantiomers and eutectics possess lower melting points than its racemate. The influence of these properties on transdermal ...
Potentially inappropriate medications use in community-based aged patients: a cross-sectional study using 2012 Beers criteria

Kuyumjian, Yara-Mary; Wakim, Samira; Zeeny, Rony; SOP; 200802837; Pharmacy Practice Department; yara-mary.kouyoumdjian@lau.edu.lb; Lebanese American University

Background Potentially inappropriate medications (PIMs) should be avoided by the aged population. The aim of this study was to assess the prevalence of PIMs among Lebanese aged outpatients using Beers criteria of 2012. ...
Idarucizumab, a humanized, monoclonal antibody fragment for immediate reversal of dabigatran

Kuyumjian, Yara; Miyares, Marta A.; Eaves, Shannon; SOP; 200802837; Pharmacy Practice Department; yara-mary.kouyoumdjian@lau.edu.lb; Lebanese American University

Objective: To evaluate the role of idarucizumab, a humanized monoclonal antibody fragment, as a specific reversal agent for the anticoagulant activity of dabigatran and to review the pharmacology, pharmacokinetic properties, ...
A multidisciplinary team-based process improves outpatient anticoagulation quality with continuous-flow left-ventricular assist devices

Kuyumjian, Yara M.; Miyares, Marta A.; Leverock, Jaime; Chaparro, Sandra; Baker, William L.; jennings, Douglas L.; SOP; 200802837; Pharmacy Practice Department; yara-mary.kouyoumdjian@lau.edu.lb; Lebanese American University

While continuous-flow left-ventricular assist devices (CF-LVAD) prolong survival in patients with heart failure who are refractory to medical therapy [1], contemporary devices expose patients to a superposed risk of both ...
Synthesis of new pyrazolo[3,4-d]pyrimidine derivatives and evaluation of their anti-inflammatory and anticancer activities

Mroueh, Mohamad; Faour, Wissam H.; Daher, Costantine F.; Abd El Razik, Heba A.; Shebaby, Wassim N.; Ashour, Hayam M.; Ragab, Hanan M.; SAS; SOM; SOP; 199590020; 200904962; 199190130; Natural Sciences; mmroueh@lau.edu.lb; wissam.faour@lau.edu.lb; cdaher@lau.edu.lb; Lebanese American University

This study reports the synthesis of two series of new purine bioisosteres comprising a pyrazolo[3,4-d]pyrimidine scaffold linked to piperazine moiety through different amide linkages. The newly synthesized compounds were ...
Wild carrot pentane-based fractions suppress proliferation of human HaCaT keratinocytes and protect against chemically-induced skin cancer

Mroueh, Mohamad A.; Ishac Taleb, Robin; El-Sibai, Mirvat; Daher, Costantine F.; Shebaby, Wassim N.; Boukamp, Petra; Bodman-Smith, Kikki; N/A; SOP; 199590020; 200901968; 200703859; 199190130; N/A; cdaher@lau.edu.lb; mirvat.elsibai@lau.edu.lb; robin.taleb@lau.edu.lb; mmroueh@lau.edu.lb; Lebanese American University

Background Previous studies in our laboratory showed that the Lebanese Daucus carota ssp. carota (wild carrot) oil extract possesses in vitro and in vivo anticancer activities. The present study aims to examine the cytotoxic ...
Cafeteria diet-fed mice is a pertinent model of obesity-induced organ damage

Zeeni, Nadine; Dimassi, Hani; Faour, Wissam H.; Dagher-Hamalian, Carole; SAS; SON; SOM; SOP; 201000400; 200603781; 200904962; 200902770; Natural Sciences; nadine.zeeni@lau.edu.lb; hani.dimassi@lau.edu.lb; wissam.faour@lau.edu.lb; carole.hamalian@lau.edu.lb; Lebanese American University

Objective This study is aimed at evaluating the effects of a cafeteria diet (obesity) mouse model on early multi-organ functional, structural, endocrine and biochemical alterations. Materials and methods Multi-organ ...
Daucus carota pentane/diethyl ether fraction inhibits motility and reduces invasion of cancer cells

Daher, Costantine F.; Mroueh, Mohamad; Taleb, Robin I.; El-Sibai, Mirvat; Zgheib, Perla; Nasrallah, Anita; SAS; SOP; 199190130; 199590020; 200901968; 200703859; Natural Sciences; cdaher@lau.edu.lb; mmroueh@lau.edu.lb; robin.taleb@lau.edu.lb; mirvat.elsibai@lau.edu.lb; Lebanese American University

Daucus carota (DC) is a herb used in folklore medicine in Lebanon to treat numerous diseases including cancer. Recent studies in our laboratory on DC oil and its fractions revealed potent anticancer activities in vitro and ...
Traumatic inferior epigastric vessel haemorrhage

Dimassi, Hani; Mohammed, Babiker Ali; Alshehri, Fahad Mohammed; SOP; 200603781; N/A; hani.dimassi@lau.edu.lb; Lebanese American University

Inferior epigastric vessel (IEV) bleeding usually results in a localised rectus sheath haematoma. This condition was thought to be uncommon and sometimes overlooked or misdiagnosed. Lately the condition has become more ...

Now showing items 81-100 of 335

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