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School of Pharmacy: Recent submissions

  • Parenteral nutrition-associated liver complications in children 
    Btaiche, Imad F.; Khalidi, Nabil; SOP; 201105289; Pharmacy Practice Department; imad.btaiche@lau.edu.lb
    Parenteral nutrition is a life-saving therapy for patients with intestinal failure. It may be associated with transient elevations of liver enzyme concentrations, which return to normal after parenteral nutrition is ...
  • Relationship Between Hyperglycemia and Infection in Critically Ill Patients 
    Btaiche, Imad F.; Butler, Simona O.; SOP; 201105289; Pharmacy Practice Department; imad.btaiche@lau.edu.lb
    Hyperglycemia is a common problem encountered in hospitalized patients, especially in critically ill patients and those with diabetes mellitus. Uncontrolled hyperglycemia may be associated with complications such as fluid ...
  • Review of the Refeeding Syndrome 
    Btaiche, Imad F.; Kraft, Micheal D.; Sacks, Gordon S.; SOP; 201105289; Pharmacy Practice Department; imad.btaiche@lau.edu.lb
    Refeeding syndrome describes a constellation of metabolic disturbances that occur as a result of reinstitution of nutrition to patients who are starved or severely malnourished. Patients can develop fluid and electrolyte ...
  • Treatment of electrolyte disorders in adult patients in the intensive care unit 
    Btaiche, Imad F.; Kraft, Micheal D.; Sacks, Gordon S.; Kudsk, Kenneth A.; SOP; 201105289; Pharmacy Practice Department; imad.btaiche@lau.edu.lb
    Purpose. The treatment of electrolyte disorders in adult patients in the intensive care unit (ICU), including guidelines for correcting specific electrolyte disorders, is reviewed. Summary. Electrolytes are involved ...
  • Pediatric Short Bowel Syndrome 
    Btaiche, Imad; Spencer, Ariel; Neega, Andreea; West, Brady; Safran, Jared; Brown, Pamela; Kuzma-O'Reilly, Barbara; Teitelbaum, Daniel H.; SOP; 201105289; Pharmacy Practice Department; imad.btaiche@lau.edu.lb
    Objective: To determine predictors of survival and of weaning off parenteral nutrition (PN) in pediatric short bowel syndrome (SBS) patients. Summary Background Data: Pediatric SBS carries extensive morbidity and high ...
  • Genetic and environmental influences on total plasma homocysteine and its role in coronary artery disease risk 
    Milane, Aline; Platt, Daniel E.; Ghassibe-Sabbagh, Michella; Youhanna, Sonia; Abchee, Antoine B.; Haber, Marc; Badro, Danielle A.; Salloum, Angelique K.; Douayhi, Bouchra; Nemr, Rita; Cazier, Jean-Baptiste; Zalloua, Pierre A.; SOP; 200904164; 200300001; N/A; aline.milane@lau.edu.lb; pierre.zalloua@lau.edu.lb
    Background Elevated levels of total plasma homocysteine are a risk factor for atherosclerotic disease. Aims The rationale behind this study is to explore the correlation between degree and site of coronary lesion ...
  • Preclinical impact of bevacizumab on brain and tumor distribution of irinotecan and temozolomide 
    Milane, Aline; Goldwirt, Lauriane; Beccaria, Kevin; Carpentier, Alexandre; Idbaih, Ahmed; Schmitt, Charlotte; LEvasseur, Camille; Labussiere, Marianne; Farinotti, Robert; Fernandez, Christine; SOP; 200904164; N/A; aline.milane@lau.edu.lb
    Glioblastoma (GBM) is the most common primary malignant brain tumour in adults. Prognosis of GBM patients is poor with median overall survival around 15 months. Temozolomide is the chemotherapeutic agent used in the standard ...
  • Student perceptions towards interprofessional education 
    Zeeni, Nadine; Bassil, Maya; Nasser, Soumana; Milane, Aline; Habre, Maha; Khazen, Georges; Asmar, Nadia; Hasbini-Danawi, Tala; Farra, Anna; Zeeenny, Rony; Hoffart, Nancy; SOP; SAS; SON; 201000400; 201102356; 199231640; 200904164; 201204374; 201105253; N/A; nadine.zeeni@lau.edu.lb; mbassil@lau.edu.lb; soumana.nasser@lau.edu.lb; aline.milane@lau.edu.lb; maha.habre@lau.edu.lb; GKhazen@lau.edu.lb
    The Lebanese American University Interprofessional Education (LAU IPE) Steps Framework consists of a five-step workshop-based series that is offered throughout the curriculum of health and social care students at an ...
  • Effectiveness of a technology-based intervention to teach evidence-based practice 
    Doumit, Rita; Zeeni, Nadine; Sukkarieh-Haraty, Ola; Milane, Aline; Long, JoAnn D.; Gannaway, Paula; Ford, Cindy; Byers, Beverly; Harrison, LaNell; Hatch, Daniel; Brown, Justin; Proper, Sharlan; White, Patricia; Song, Huaxin; SOP; SAS; SON; 200200810; 201000400; 201005492; 200904164; N/A; rita.doumit@lau.edu.lb; nadine.zeeni@lau.edu.lb; ola.sukkarieh@lau.edu.lb; aline.milane@lau.edu.lb
    Background: As the world becomes increasingly digital, advances in technology have changed how students access evidence-based information. Research suggests that students overestimate their ability to locate quality ...
  • Role of two efflux proteins, ABCB1 and ABCG2 in blood-brain barrier transport of bromocriptine in a murine model of MPTP-induced dopaminergic degeneration 
    Milane, Aline; Vautier, Sarah; Fernandez, Christine; Chacun, Helene; Lacomble, Luccette; Farinotti, Robert; SOP; 200904164; N/A; aline.milane@lau.edu.lb
    Purpose: MPTP-induced dopaminergic degeneration is an experimental model commonly used to explore Parkinson’s disease. Cerebral drug transport by ABC transporters in MPTP models has never been reported. Methods: We have ...
  • Interactions between antiparkinsonian drugs and ABCB1/P-glycoprotein at the blood–brain barrier in a rat brain endothelial cell model 
    Vautier, Sarah; Milane, Aline; Fernandez, Christine; Buyse, Marion; Chacun, Helene; Farinotti, Robert; SOP; 200904164; N/A; aline.milane@lau.edu.lb
    Parkinson's disease is a neurodegenerative disorder that requires treatment by dopaminergic agonists, which may be responsible for central side effects. We hypothesized that the efflux transporter ABCB1/P-glycoprotein ...
  • Interactions between riluzole and ABCG2/BCRP transporter 
    Milane, Aline; Vautier, Sarah; Chacun, Helene; Meininger, Vincent; Bensimon, Gilbert; Farinotti, Robert; Fernandez, Christine; SOP; 200904164; N/A; aline.milane@lau.edu.lb
    Amyotrophic lateral sclerosis (ALS) is a neurodegenerative fatal disease. Drugs used in this disease need to cross the blood–brain barrier (BBB). Only riluzole is approved for ALS treatment. We have investigated riluzole ...
  • P-glycoprotein expression and function are increased in an animal model of amyotrophic lateral sclerosis 
    Milane, Aline; Fernandez, Christine; Dupuis, Luc; Buyse, Marion; Loeffler, Jean-Philippe; Farinotti, Robert; Meininger, Vincent; Bensimon, Gilbert; SOP; 200904164; N/A; aline.milane@lau.edu.lb
    The efflux pumps located at the blood–brain barrier (BBB) prevent drugs entering the brain. As such, efflux pumps are a major obstacle to drug brain distribution. Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative ...
  • Brain and plasma riluzole pharmacokinetics 
    Milane, Aline; Tortolano, Lionel; Fernadez, Christine; Bensimon, Gilbert; Meininger, Vincent; Farinotti, Robert; SOP; 200904164; N/A; aline.milane@lau.edu.lb
    Purpose. Amyotrophic lateral sclerosis is a fatal neurodegenerative disease characterized by the loss of motorneurons. The only drug approved is riluzole. Minocycline is an antibiotic with numerous neuroprotective ...
  • Minocycline and riluzole brain disposition 
    Milane, Aline; Fernandez, Christine; Vautier, Sarah; Meininger, Vincent; Farinotti, Robert; Bensimon, Gilbert; SOP; 200904164; N/A; aline.milane@lau.edu.lb
    Amyotrophic lateral sclerosis is a neurodegenerative fataldisease. The only drug recognized to increase the survivaltime is riluzole(RLZ). In animal models, minocycline (MNC)delayed the onset of the disease and increased ...
  • Olodaterol for the treatment of chronic obstructive pulmonary disease 
    Kabbara, Wissam K.; Ramadan, Wijdan H.; Abilmona, Rosa M.; SOP; 200104485; 199312180; Pharmacy Practice Department; wissam.kabbara@lau.edu.lb; wramadan@lau.edu.lb
    Purpose. Published data on the pharmacology, pharmacokinetics, efficacy, and safety of the once-daily, long-acting β2-agonist (LABA) olodaterol are reviewed. Summary. Olodaterol (Striverdi Respimat, Boehringer Ingelheim), ...
  • Acute and fatal isoniazid-induced hepatotoxicity 
    Kabbara, Wissam K.; Sarkis, Aline T.; Saroufim, Paola G.; SOP; 200104485; Pharmacy Practice Department; wissam.kabbara@lau.edu.lb
    This paper describes a case of an acute and fatal isoniazid-induced hepatotoxicity and provides a review of the literature. A 65-year-old female diagnosed with latent Mycobacterium tuberculosis infection was receiving oral ...
  • Simplicity, safety, and acceptability of insulin pen use versus the conventional vial/syringe device in patients with type 1 and type 2 diabetes mellitus in Lebanon 
    Kabbara, Wissam K.; Ramadan, Wijdan H.; Khreis, Noura A.; SOP; 200104485; 199312180; Pharmacy Practice Department; wissam.kabbara@lau.edu.lb; wramadan@lau.edu.lb
    Background The aim of the study was to evaluate the simplicity, safety, patients’ preference, and convenience of the administration of insulin using the pen device versus the conventional vial/syringe in patients with ...
  • Sitagliptin/Simvastatin 
    Kabbara, Wissam K.; Ramadan, Wijdan H.; SOP; 200104485; 199312180; Pharmacy Practice Department; wissam.kabbara@lau.edu.lb; wramadan@lau.edu.lb
    Background The purpose of this study was to review the current literature and information on the combination product Juvisync™ (sitagliptin + simvastatin), which was approved by the US Food and Drug Administration in ...
  • Nitrofurantoin-induced pulmonary toxicity 
    Kabbara, Wissam K.; Kordahi, Melissa C.; SOP; 200104485; Pharmacy Practice Department; wissam.kabbara@lau.edu.lb
    This paper describes a case of lung injury attributed to the use of Nitrofurantoin and a review of the relevant literature. An 88-year-old woman was admitted to the floor for the evaluation of recent symptoms of dyspnea, ...

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