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School of Pharmacy: Recent submissions

  • Carcinogenic and neurotoxic risks of acrylamide and heavy metals from potato and corn chips consumed by the Lebanese population 
    Mroueh, Mohamad; Korfali, Samira; Taleb, Robin I.; Hariri, Essa; Abboud, Martine I.; Demerdjian, Sally; SOP; 199590020; 197829160; 200901968; N/A; mmroueh@lau.edu.lb; skorfali@lau.edu.lb; robin.taleb@lau.edu.lb
    The present study aims to quantify acrylamide and metals in potato and corn chips and to determine their carcinogenic and neurotoxic risks. Gas chromatography mass spectrometry analysis revealed that the average acrylamide ...
  • β-2-himachalen-6-ol 
    Taleb, Robin I.; El-Sibai, Mirvat; Daher, Costantine; Mroueh, Mohamad; Najm, Paul; Shebaby, Wassim; Boulos, Joelle C.; Demirdjian, Sally; Hariri, Essa; SOP; SAS; 200901968; 200703859; 199190130; 199590020; N/A; robin.taleb@lau.edu.lb; mirvat.elsibai@lau.edu.lb; cdaher@lau.edu.lb; mmroueh@lau.edu.lb
    Daucus carota ssp. carota, also known as wild carrot, is a commonly used herb in Lebanese folk medicine to treat several ailments including cancer. Previous studies in our laboratories showed that the Daucus carota oil ...
  • Metal concentration in commonly used medicinal herbs and infusion by lebanese population 
    Mroueh, Mohamad; Korfali, Samira; Al-Zein, Mohammad; Salem, Rosin; SOP; 199590020; 197829160; N/A; mmroueh@lau.edu.lb; skorfali@lau.edu.lb
    The levels of K, Ca, Fe, Zn, Cu, Mn, As, Cd, Cr, and Pb in commonly used medicinal herbs and their infusions by the Lebanese were analyzed by energy dispersive X-ray fluorescence and ASS techniques, respectively. The mean ...
  • Sciatic nerve stimulation activates the retrotrapezoid nucleus (RTN) in anesthetized rats 
    Kanbar, Roy; Stornetta, Ruth L.; Guyenet, Patrice G.; SOP; 201005298; N/A; roy.kanbar@lau.edu.lb
    Retrotrapezoid (RTN) neurons sustain breathing automaticity. These neurons have chemoreceptor properties but their firing is also regulated by multiple synaptic inputs of uncertain function. Here we test whether RTN, like ...
  • Breathing frequency (fR) is no longer under chemoreflex control during REM sleep 
    Kanbar, Roy; Burke, Peter; Basrting, Tyler; viar, Kenneth; Stornetta, Ruth; Guyenet, Patrice; SOP; 201005298; N/A; roy.kanbar@lau.edu.lb
    Objective: To define the contribution of central chemoreception in general and the retrotrapezoid nucleus (RTN) in particular to the regulation of breathing in REM sleep. Methods: EEG, neck EMG, blood pressure, fR and tidal ...
  • Hypoxia silences retrotrapezoid nucleus respiratory chemoreceptors via alkalosis 
    Kanbar, Roy; Basting, Tyler M.; Burke, Peter G. R.; Viar, Kenneth E.; Stornetta, Daniel S.; Stornetta, Ruth L.; Guyenet, Patrice G.; SOP; 201005298; N/A; roy.kanbar@lau.edu.lb
    In conscious mammals, hypoxia or hypercapnia stimulates breathing while theoretically exerting opposite effects on central respiratory chemoreceptors (CRCs). We tested this theory by examining how hypoxia and hypercapnia ...
  • State-dependent control of breathing by the retrotrapezoid nucleus 
    Kanbar, Roy; Burke, Peter G. R.; Basting, Tyler M.; Hodges, Walter M.; Viar, Kenneth E.; Stornetta, Ruth L.; Guyenet, Patrice G.; SOP; 20100529; N/A; roy.kanbar@lau.edu.lb
    Breathing has different characteristics during quiet wake, non-REM or REM sleep, including variable dependence on PCO2 . We investigated whether the retrotrapezoid nucleus (RTN), a proton-sensitive structure that mediates ...
  • Selective optogenetic stimulation of the retrotrapezoid nucleus in sleeping rats activates breathing without changing blood pressure or causing arousal or sighs 
    Kanbar, Roy; Burke, Peter G. R.; Viar, Kenneth E.; Stornetta, Ruth L.; Guyenet, Patrice G.; SOP; 201005298; N/A; roy.kanbar@lau.edu.lb
    Combined optogenetic activation of the retrotrapezoid nucleus (RTN; a CO2/proton-activated brainstem nucleus) with nearby catecholaminergic neurons (C1 and A5), or selective C1 neuron stimulation, increases blood pressure ...
  • Proton detection and breathing regulation by the retrotrapezoid nucleus 
    Kanbar, Roy; Guyenet, Patrice G.; Bayliss, Douglas A.; Stornetta, Ruth L.; Ludwig, Marie-Gabrielle; Kumar, Natasha N.; Shi, Yingtang; Burke, Peter G. R.; Basting, Tyler M.; Holloway, Benjamin; Wenker, Ian C.; SOP; 201005298; N/A; roy.kanbar@lau.edu.lb
    Abstract We discuss recent evidence which suggests that the principal central respiratory chemoreceptors are located within the retrotrapezoid nucleus (RTN) and that RTN neurons are directly sensitive to [H+]. RTN neurons ...
  • Sensibilisation du baroréflexe sympathique durant le stress émotionnel chez le rat 
    Kanbar, R.; Orea, V.; BArres, C.; Julien, C.; SOP; 201005298; N/A; roy.kanbar@lau.edu.lb
    Le baroréflexe artériel, et plus particulièrement sa composante sympathique, pourrait limiter les effets hypertenseurs du stress émotionnel. Il a cependant été proposé que ce type de stress inhibe, voire abolit, le ...
  • The sympathetic baroreflex is enhanced during emotional stress in rats 
    Kanbar, Roy; Orea, Valerie; Barres, Valerie; Julien, Claude; SOP; 201005298; N/A; roy.kanbar@lau.edu.lb
  • C1 neurons excite locus coeruleus and A5 noradrenergic neurons along with sympathetic outflow in rats 
    Kanbar, R.; Abbott, S.B.; Bochorishvili, G.; Coates, M.B.; Stornetta, R.L.; SOP; 201005298; N/A; roy.kanbar@lau.edu.lb
    C1 neurons activate sympathetic tone and stimulate the hypothalamic–pituitary–adrenal axis in circumstances such as pain, hypoxia or hypotension. They also innervatepontine noradrenergic cell groups, including the locus ...
  • Transfer function analysis between arterial pressure and renal sympathetic nerve activity at cardiac pacing frequencies in the rat 
    Kanbar, Roy; Orea, Valerie; Chapuis, Bruno; Barres, Christian; Julien, Claude; SOP; 201005298; N/A; roy.kanbar@lau.edu.lb
    This study examined the possible influence of changes in heart rate (HR) on the gain of the transfer function relating renal sympathetic nerve activity (RSNA) to arterial pressure (AP) at HR frequency in rats. In seven ...
  • Baroreflex control of lumbar and renal sympathetic nerve activity in conscious rats 
    Kanbar, Roy; Chapuis, Bruno; Orea, Valerie; Barres, Christian; Julien, Claude; SOP; 201005298; N/A; roy.kanbar@lau.edu.lb
    This study compared the baroreflex control of lumbar and renal sympathetic nerve activity (SNA) in conscious rats. Arterial pressure (AP) and lumbar and renal SNA were simultaneously recorded in six freely behaving rats. ...
  • Regulation of visceral sympathetic tone by A5 noradrenergic neurons in rodents 
    Kanbar, Roy; Depuy, Gavin H.; West, Ruth L.; Guyenet, Stornetta and Patrice G.; SOP; 201005298; N/A; roy.kanbar@lau.edu.lb
    The ventrolateral pons contains the A5 group of noradrenergic neurons which regulate the circulation and probably breathing. The present experiments were designed to identify these neurons definitively in vivo, to examine ...
  • A transfer function method for the continuous assessment of baroreflex control of renal sympathetic nerve activity in rats 
    Kanbar, Roy; Orea, Valerie; Chapuis, Bruno; Barres, Christian; Julien, Claude; SOP; 201005298; N/A; roy.kanbar@lau.edu.lb
    The present study examined whether the gain of the transfer function relating cardiac-related rhythm of renal sympathetic nerve activity (RSNA) to arterial pressure (AP) pulse might serve as a spontaneous index of sympathetic ...
  • Photostimulation of phox2b medullary neurons activates cardiorespiratory function in conscious rats 
    Kanbar, Roy; Stornetta, Ruth L.; Cash, Devin R.; Lewis, Stephen L.; Guyenet, Patrice G.; SOP; 201005298; N/A; roy.kanbar@lau.edu.lb
    Rationale: Hypoventilation is typically treated with positive pressure ventilation or, in extreme cases, by phrenic nerve stimulation. This preclinical study explores whether direct stimulation of central chemoreceptors ...
  • Control of breathing by raphe obscurus serotonergic neurons in mice 
    Kanbar, Roy; Depuy, Seth D.; Coates, Melissa B.; Stometta, Ruth L.; Guyenet, Patrice G.; SOP; 201005298; N/A; roy.kanbar@lau.edu.lb
    We used optogenetics to determine the global respiratory effects produced by selectively stimulating raphe obscurus (RO) serotonergic neurons in anesthetized mice and to test whether these neurons detect changes in the ...
  • Baroreflex control of renal sympathetic nerve activity during air-jet stress in rats 
    Kanbar, Roy; Oprea, Valerie; Barres, Christian; Julien, Claude; SOP; 201005298; N/A; roy.kanbar@lau.edu.lb
    The effects of acute emotional stress on the sympathetic component of the arterial baroreceptor reflex have not yet been described in conscious animals and humans. Arterial pressure (AP) and renal sympathetic nerve activity ...
  • Central CO2 chemoreception and integrated neural mechanisms of cardiovascular and respiratory control 
    Kanbar, Roy; Guyenet, Patrice G.; Stornetta, Ruth L.; Abbott, Stephen B.G.; Depuy, Seth D.; Fortuna, Michal G.; SOP; 201005298; N/A; roy.kanbar@lau.edu.lb
    In this review, we examine why blood pressure (BP) and sympathetic nerve activity (SNA) increase during a rise in central nervous system (CNS) Pco2 (central chemoreceptor stimulation). CNS acidification modifies SNA by two ...

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