.

Recently added

LAUR Repository

School of Arts and Sciences: Recent submissions

  • Molecular mechanisms of Tau protein aggregation inhibition 
    Akoury, Elias (Niedersächsische Staats-und Universitätsbibliothek Göttingen, )
    Of all neurodegenerative diseases, Alzheimer´s Disease is the most widespread dementia syndrome, exhibiting progressive memory loss and intellectual abilities. One of the pathological hallmarks of this disease is associated ...
  • Isolation and structural elucidation of rosmarinic acid by nuclear magnetic resonance spectroscopy 
    Akoury, Elias
    Lemon balm is a herbal tea known for its therapeutic practice in soothing stomach cramps, indigestion and nausea. One of its chemical components is rosmarinic acid, known for its anti-inflammatory and antiviral activities ...
  • Mechanismus der phenothiazin‐induzierten hemmung der Tau‐aggregation 
    Akoury, Elias; Pickhardt, Marcus; Gajda, Michal; Biernat, Jacek; Mandelkow, Eckhard; Zweckstetter, Markus
  • Remodeling of the conformational ensemble of the repeat domain of tau by an aggregation enhancer 
    Akoury, Elias; Mukrasch, Marco D.; Biernat, Jacek; Tepper, Katharina; Ozenne, Valery; Mandelkow, Eckhard; Blackedge, Martin; Zweckstetter, Markus
    Misfolding of the microtubule‐associated protein Tau is a hallmark of Alzheimer disease and several other neurodegenerative disorders. Because of the dynamic nature of the Tau protein, little is known about the changes in ...
  • Surfactant adsorption kinetics in microfluidics 
    Akoury, Elias; Semin, Benoit; Maes, Florine; Riechers, Birte; Gruner, Philipp; Baret, Jean-Christophe
    Emulsions are metastable dispersions. Their lifetimes are directly related to the dynamics of surfactants. We design a microfluidic method to measure the kinetics of adsorption of surfactants to the droplet interface, a ...
  • The active Hsc70/tau complex can be exploited to enhance tau turnover without damaging microtubule dynamics 
    Akoury, Elias; Martin, Mackenzie D.; Assimon, Victoria A.; Borysov, Sergiy
    The pathological accumulation of abnormally hyperphosphorylated and aggregated tau, a neuronal microtubule (MT)-associated protein that functions to maintain MT stability, is implicated in a number of hereditary and sporadic ...
  • Inhibition of Tau filament formation by conformational modulation 
    Akoury, Elias; Gajdat, Michal; Pickhardt, Marcus
    Antiaggregation drugs play an important role in therapeutic approaches for Alzheimer’s disease. Although a large number of small molecules that inhibit the aggregation of the tau protein have been identified, little is ...
  • Imbalance of Hsp70 family variants fosters tau accumulation 
    Akoury, Elias; Jinwal, Umesh K.; Abisambra, John C.; Thompson, Andrea D.; Zhang, Juan
    Dysfunctional tau accumulation is a major contributing factor in tauopathies, and the heat-shock protein 70 (Hsp70) seems to play an important role in this accumulation. Several reports suggest that Hsp70 proteins can cause ...
  • Mechanistic basis of phenothiazine‐driven inhibition of Tau aggregation 
    Akoury, Elias; Pickhardt, Marcus; Gajda, Michal; Biernat, Jacek; Mandelkow, Eckhard; Zweckstetter, Markus
    Blues brothers: Aggregation of the Tau protein is a key event in Alzheimer's disease and Tau aggregation inhibitors are important as potential drugs. Phenothiazines, such as methylene blue and its azure derivatives, have ...
  • β-Sheet core of Tau paired helical filaments revealed by solid-state NMR 
    Akoury, Elias; Daebel, Venita; Loquet, Antoine; Zweckstetter, Markus
    One of the hallmarks of Alzheimer’s disease is the self-assembly of the microtubule-associated protein tau into fibers termed “paired helical filaments” (PHFs). However, the structural basis of PHF assembly at atomic detail ...
  • Hsp90-Tau complex reveals molecular basis for specificity in chaperone action 
    Akoury, Elias; Duarte, Afonso M.S.; Didenko, Tatiana; Radil, Martina
    Protein folding in the cell relies on the orchestrated action of conserved families of molecular chaperones, the Hsp70 and Hsp90 systems. Hsp70 acts early and Hsp90 late in the folding path, yet the molecular basis of this ...
  • Scrambled Prime Key Encryption 
    Haraty, Ramzi A.; Haidar, Imane; Haidar, Ali Massoud (The Association for Computing MachineryNew York, NY, USA, )
    Information security has become an important issue in the modern world as the popularity of internet commerce and communication technologies have emerged, making them a prospective medium to security threats. To surmount ...
  • Stimulus equivalence and attitudes 
    Grey, Ian M.; Dermot, Barnes
    Two studies examine the contribution of stimulus equivalence procedures to the study of attitude formation and attitude change. Subjects' behavior was in accordance with the expected equivalence relations.
  • The handbook of intellectual disability and clinical psychology practice 
    SAS; 201806288; Social Sciences; Grey, Ian; McClean, Brian; ian.grey@lau.edu.lb; Lebanese American University (Routlege, )
  • (k, l)-Clustering for Transactional Data Streams Anonymization 
    Haraty, Ramzi; Tekli, Jimmy; Al Bouna, Bechara; Issa, Youssef Bou; Kamradt, Marc (SpringerCham, Switzerland, )
    In this paper, we address the correlation problem in the anonymization of transactional data streams. We propose a bucketization-based technique, entitled (k, l)-clustering to prevent such privacy breaches by ensuring that ...
  • Axes-Based Encryption Key 
    Haraty, Ramzi A.; Haidar, Imane; Haidar, Ali Massoud (IEEEPiscataway, N.J., )
    Security has always been a privilege for governments and banks, from the old Egyptian civilization to the latest technologies. Nowadays, security has become an essential part in our daily life; from protecting mobile chats ...
  • Associating learning technology to sustain the environment through green mobile applications 
    Haraty, Ramzi A.; Bitar, Georges
    Today, there is a great urge to “Go Green” in many facets in our life, such as reducing the consumption of energy and creating more eco-friendly products as a solution to reduce the crisis that we might face in the future. ...
  • The handbook of intellectual disability and clinical psychology practice 
    SAS; 201806288; Social Sciences; Grey, Ian; McClean, Brian; ian.grey@lau.edu.lb; Lebanese American University (Routledge, )
  • Indexing Arabic texts using association rule data mining 
    Haraty, Ramzi A.; Nasrallah, Rouba
    Purpose The purpose of this paper is to propose a new model to enhance auto-indexing Arabic texts. The model denotes extracting new relevant words by relating those chosen by previous classical methods to new words using ...
  • The handbook of intellectual disability and clinical psychology practice 
    SAS; 201806288; Social Sciences; Grey, Ian; McClean, Brian; ian.grey@lau.edu.lb; Lebanese American University (Routledge, )

Search LAUR


Advanced Search

Browse

My Account